Liver X Receptor Activation with an Intranasal Polymer Therapeutic Prevents Cognitive Decline without Altering Lipid Levels

[Image: see text] The progressive accumulation of amyloid-beta (Aβ) in specific areas of the brain is a common prelude to late-onset of Alzheimer’s disease (AD). Although activation of liver X receptors (LXR) with agonists decreases Aβ levels and ameliorates contextual memory deficit, concomitant hy...

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Detalles Bibliográficos
Autores principales: Navas Guimaraes, María Eugenia, Lopez-Blanco, Roi, Correa, Juan, Fernandez-Villamarin, Marcos, Bistué, María Beatriz, Martino-Adami, Pamela, Morelli, Laura, Kumar, Vijay, Wempe, Michael F., Cuello, A. C., Fernandez-Megia, Eduardo, Bruno, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488954/
https://www.ncbi.nlm.nih.gov/pubmed/33666411
http://dx.doi.org/10.1021/acsnano.0c09159

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