Cargando…

Bai-He-Gu-Jin-Tang formula suppresses lung cancer via AKT/GSK3β/β-catenin and induces autophagy via the AMPK/mTORC1/ULK1 signaling pathway

Aims: Bai-He-Gu-Jin-Tang (BHGJT) is a classic Chinese formula used to treat lung cancer, while the underlying molecular mechanism remains obscure. The aim of the study was to investigate the molecular mechanism of BHGJT on lung cancer and demonstrate the potential for synergistic treatment combining...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Quhui, Li, Da, Sun, Taoli, Liu, Jian, Ou, Huiping, Zheng, Lei, Hou, Xuyang, Li, Wenqun, Fan, Fuyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489124/ https://www.ncbi.nlm.nih.gov/pubmed/34659548 http://dx.doi.org/10.7150/jca.62779

Ejemplares similares

The mechanism of Bai He Gu Jin Tang against non-small cell lung cancer revealed by network pharmacology and molecular docking
por: Xie, Rui-fei, et al.
Publicado: (2022)

ULK1 Regulates Melanin Levels in MNT-1 Cells Independently of mTORC1
por: Kalie, Eyal, et al.
Publicado: (2013)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

Fine-tuning of AMPK–ULK1–mTORC1 regulatory triangle is crucial for autophagy oscillation
por: Holczer, Marianna, et al.
Publicado: (2020)

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
por: Xu, Zhi-Xiang, et al.
Publicado: (2019)

Turning acne on/off via mTORC1
por: Danby, F William
Publicado: (2013)

Protective effect of compatible herbs in Jin-Gu-Lian formula against Alangium chinense-induced neurotoxicity via oxidative stress, neurotransmitter metabolisms, and pharmacokinetics
por: Lian, Dongyin, et al.
Publicado: (2023)

mTORC in β cells: more Than Only Recognizing Comestibles
por: Maedler, Kathrin, et al.
Publicado: (2017)

PEBP4 Directs the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2
por: Chen, Qiongfeng, et al.
Publicado: (2022)

Rapamycin induces autophagy to alleviate acute kidney injury following cerebral ischemia and reperfusion via the mTORC1/ATG13/ULK1 signaling pathway
por: Su, Yang, et al.
Publicado: (2018)

mTORC1 accelerates retinal development via the immunoproteasome
por: Choi, Ji-Heon, et al.
Publicado: (2018)

SNAT7 regulates mTORC1 via macropinocytosis
por: Meng, Delong, et al.
Publicado: (2022)

Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis
por: Xiong, Xiufang, et al.
Publicado: (2018)

Xanthohumol Inhibits TGF-β1-Induced Cardiac Fibroblasts Activation via Mediating PTEN/Akt/mTOR Signaling Pathway
por: Jiang, Chuanhao, et al.
Publicado: (2020)

TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2
por: Zhang, Zhiyong, et al.
Publicado: (2019)

Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
por: Tao, Huishan, et al.
Publicado: (2021)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Jin-Wu-Jian-Gu Formulation Attenuates Rheumatoid Arthritis by Inhibiting the IL33-ST2 Signaling Pathway
por: Lu, Daomin, et al.
Publicado: (2022)

Moderate Autophagy Inhibits Vascular Smooth Muscle Cell Senescence to Stabilize Progressed Atherosclerotic Plaque via the mTORC1/ULK1/ATG13 Signal Pathway
por: Luo, Zhenli, et al.
Publicado: (2017)

TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression
por: Das, Falguni, et al.
Publicado: (2014)

Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation.
por: Balcazar Morales, Norman, et al.
Publicado: (2012)

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1
por: Bachar, Etti, et al.
Publicado: (2009)

Regulation of bone formation by baicalein via the mTORC1 pathway
por: Li, Sheng-fa, et al.
Publicado: (2015)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Modified Si–Jun–Zi–Tang Attenuates Airway Inflammation in a Murine Model of Chronic Asthma by Inhibiting Teff Cells via the mTORC1 Pathway
por: Jin, Hualiang, et al.
Publicado: (2019)

Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling
por: Chen, Xiao-Yu, et al.
Publicado: (2017)

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
por: Blandino-Rosano, Manuel, et al.
Publicado: (2017)

mTORC1 is required for epigenetic silencing during β-cell functional maturation
por: Ni, Qicheng, et al.
Publicado: (2022)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Isolation and characterization of nanometre aggregates from a Bai-Hu-Tang decoction and their antipyretic effect
por: Lü, Shaowa, et al.
Publicado: (2018)

mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1
por: Huynh, HoangDinh, et al.
Publicado: (2018)

P53 suppresses ribonucleotide reductase via inhibiting mTORC1
por: He, Zhengfu, et al.
Publicado: (2017)

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor
por: Jewell, Jenna L, et al.
Publicado: (2019)

Leucine regulates autophagy via acetylation of the mTORC1 component raptor
por: Son, Sung Min, et al.
Publicado: (2020)

GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway
por: Guo, Xinzheng, et al.
Publicado: (2016)

Acute Conditioning of Antigen-Expanded CD8(+) T Cells via the GSK3β-mTORC Axis Differentially Dictates Their Immediate and Distal Responses after Antigen Rechallenge
por: Taborska, Pavla, et al.
Publicado: (2020)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_sddq1e5n7tec9skaidhhrtkk3m