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K-134, a phosphodiesterase 3 inhibitor, reduces vascular inflammation and hypoxia, and prevents rupture of experimental abdominal aortic aneurysms

OBJECTIVE: Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease, which frequently results in fatal rupture; however, no pharmacologic treatment exists to inhibit AAA growth and prevent rupture. In this study, we investigated whether K-134, a novel phosphodiesterase 3 inhibitor, could li...

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Detalles Bibliográficos
Autores principales:	Unno, Naoki, Tanaka, Hiroki, Yata, Tatsuro, Kayama, Takafumi, Yamanaka, Yuta, Tsuyuki, Hajime, Sano, Masaki, Inuzuka, Kazunori, Naruse, Ena, Takeuchi, Hiroya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Basic Reserch Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489215/ https://www.ncbi.nlm.nih.gov/pubmed/34617050 http://dx.doi.org/10.1016/j.jvssci.2020.09.005

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