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Intracellular drug binding affinities by NMR

A commentary on the article by Luchinat et al. [(2021), Acta Cryst. D77, 1247–1258] where they describe an approach to identify the details of a compound binding to a molecular target using in-cell NMR to provide intracellular binding affinities.

Detalles Bibliográficos
Autor principal: Madl, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489227/
https://www.ncbi.nlm.nih.gov/pubmed/34605425
http://dx.doi.org/10.1107/S2059798321010135
Descripción
Sumario:A commentary on the article by Luchinat et al. [(2021), Acta Cryst. D77, 1247–1258] where they describe an approach to identify the details of a compound binding to a molecular target using in-cell NMR to provide intracellular binding affinities.