Cargando…

Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patients

OBJECTIVE: Little is known about CSF profiles in patients with acute COVID-19 infection and neurological symptoms. Here, CSF was tested for SARS-CoV-2 RNA and inflammatory cytokines and chemokines and compared to controls and patients with known neurotropic pathogens. METHODS: CSF from twenty-seven...

Descripción completa

Detalles Bibliográficos
Autores principales:	Normandin, Erica, Holroyd, Kathryn B., Collens, Sarah I., Shaw, Bennett M., Siddle, Katherine J., Adams, Gordon, Rudy, Melissa, Solomon, Isaac H., Anahtar, Melis N., Lemieux, Jacob E., Trombetta, Bianca A., Kivisakk, Pia, Arnold, Steven E., Rapalino, Otto, Piantadosi, Anne L., Sen, Pritha, Rosenberg, Eric S., Branda, John, Sabeti, Pardis C., Mukerji, Shibani S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489278/ https://www.ncbi.nlm.nih.gov/pubmed/34678659 http://dx.doi.org/10.1016/j.jns.2021.120023

Ejemplares similares

Powassan Virus Neuropathology and Genomic Diversity in Patients With Fatal Encephalitis
por: Normandin, Erica, et al.
Publicado: (2020)

A53 Systematic application of metagenomics NGS to identify and sequence viral pathogens in infections of the central nervous system
por: Piantadosi, Anne, et al.
Publicado: (2018)

High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection
por: Normandin, Erica, et al.
Publicado: (2023)

Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19
por: Conklin, John, et al.
Publicado: (2021)

Neuropathological Features of Covid-19
por: Solomon, Isaac H., et al.
Publicado: (2020)

Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System
por: Ahmed, Saima, et al.
Publicado: (2022)

868. Prospective Pathogen Detection in Patients With Central Nervous System Inflammation Using Metagenomic Sequencing
por: Piantadosi, Anne, et al.
Publicado: (2018)

Efficient Nucleic Acid Extraction and 16S rRNA Gene Sequencing for Bacterial Community Characterization
por: Anahtar, Melis N., et al.
Publicado: (2016)

Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis
por: Piantadosi, Anne, et al.
Publicado: (2017)

346. Eastern Equine Encephalitis and Use of Intravenous Immunoglobulin Therapy and High-Dose Steroids
por: Collens, Sarah I, et al.
Publicado: (2020)

Eastern equine encephalitis and use of IV immunoglobulin therapy and high-dose steroids
por: Wilcox, Douglas R., et al.
Publicado: (2020)

985. Pooled RNA Metagenomics to Enable Scalable, Unbiased Pathogen Detection and Surveillance
por: Messer, Katelyn S, et al.
Publicado: (2023)

Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing
por: Piantadosi, Anne, et al.
Publicado: (2018)

Development of Cas13a-based Assays for Neisseria gonorrhoeae Detection and Gyrase A Determination
por: Allan-Blitz, Lao-Tzu, et al.
Publicado: (2023)

Development of Cas13a-based assays for Neisseria gonorrhoeae detection and gyrase A determination
por: Allan-Blitz, Lao-Tzu, et al.
Publicado: (2023)

Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis
por: Piantadosi, Anne, et al.
Publicado: (2021)

CSF/serum quotient graphs for the evaluation of intrathecal C(4 )synthesis
por: Padilla-Docal, Barbara, et al.
Publicado: (2009)

Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications
por: Belov, Vasily, et al.
Publicado: (2021)

Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy
por: Sun, Weiwei, et al.
Publicado: (2023)

Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy
por: Sun, Weiwei, et al.
Publicado: (2023)

Development of a qualitative real-time RT-PCR assay for the detection of SARS-CoV-2: A guide and case study in setting up an emergency-use, laboratory-developed molecular assay
por: Anahtar, Melis N., et al.
Publicado: (2020)

Are CSF CXCL13 concentrations solely dependent on intrathecal production? A commentary on “Chemokine CXCL13 in serum, CSF, and blood–CSF barrier function”
por: DiSano, Krista D., et al.
Publicado: (2021)

Distinguishing Severe Acute Respiratory Syndrome Coronavirus 2 Persistence and Reinfection: A Retrospective Cohort Study
por: Turbett, Sarah E, et al.
Publicado: (2022)

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer
por: Yang, Lijun, et al.
Publicado: (2013)

1988. Development of a Laboratory Stewardship Algorithm for Anaplasma phagocytophilum Polymerase Chain Reaction Testing
por: Anahtar, Melis, et al.
Publicado: (2018)

Clinical, Laboratory, and Radiologic Characteristics of Patients With Initial False-Negative Severe Acute Respiratory Syndrome Coronavirus 2 Nucleic Acid Amplification Test Results
por: Dugdale, Caitlin M, et al.
Publicado: (2020)

Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab
por: Solomon, Isaac H., et al.
Publicado: (2021)

Clinical Assessment and Validation of a Rapid and Sensitive SARS-CoV-2 Test Using Reverse Transcription Loop-Mediated Isothermal Amplification Without the Need for RNA Extraction
por: Anahtar, Melis N, et al.
Publicado: (2020)

Analysis of CSF D-Dimer to Identify Intrathecal Fibrin-Driven Autoimmunity in Patients With Multiple Sclerosis
por: Schaller-Paule, Martin A., et al.
Publicado: (2022)

Multiplexed detection of bacterial nucleic acids using Cas13 in droplet microarrays
por: Thakku, Sri Gowtham, et al.
Publicado: (2022)

Model-directed generation of CRISPR-Cas13a guide RNAs designs artificial sequences that improve nucleic acid detection
por: Mantena, Sreekar, et al.
Publicado: (2023)

Nucleic acid oxidation is associated with biomarkers of neurodegeneration in CSF in people with HIV
por: Ellis, Ronald J., et al.
Publicado: (2020)

Development of a qualitative real-time RT-PCR assay for the detection of SARS-CoV-2: a guide and case study in setting up an emergency-use, laboratory-developed molecular microbiological assay
por: Anahtar, Melis N, et al.
Publicado: (2021)

1459. Whole Genome Sequencing Analysis of Enterococcus faecium Clinical Isolates Reveals High Strain Diversity and High Accuracy Prediction of Antimicrobial Resistance
por: Anahtar, Melis N, et al.
Publicado: (2020)

Evaluation of Three Commercial SARS-CoV-2 Serologic Assays and Their Performance in Two-Test Algorithms
por: Turbett, Sarah E., et al.
Publicado: (2020)

Prolonged Intubation in Patients With Prior Cerebrovascular Disease and COVID-19
por: Mukerji, Shibani S., et al.
Publicado: (2021)

It’s Not You, It’s SOSA: A Case Study on Breaking Up With an FDA-Cleared Susceptibility Testing System’s Oxacillin Results for Staphylococcus spp. Other Than S. aureus and S. lugdunensis
por: Yang, Christine, et al.
Publicado: (2022)

Temporal Patterns and Drug Resistance in CSF Viral Escape Among ART-Experienced HIV-1 Infected Adults
por: Mukerji, Shibani S., et al.
Publicado: (2017)

DNA spike-ins enable confident interpretation of SARS-CoV-2 genomic data from amplicon-based sequencing
por: Lagerborg, Kim A., et al.
Publicado: (2021)

CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort
por: Senel, Makbule, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f20a5cegq99mddjrtcna739aa1