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Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships

Steroidal alkaloids contain both steroidal and alkaloid properties in terms of chemical properties and pharmacological activities. Due to outstanding biological activities such as alkaloids and similar pharmacological effects to other steroids, steroidal alkaloids have received special attention in...

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Autores principales: Huang, Ying, Li, Gen, Hong, Chong, Zheng, Xia, Yu, Haiyang, Zhang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489381/
https://www.ncbi.nlm.nih.gov/pubmed/34616681
http://dx.doi.org/10.3389/fonc.2021.733369
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author Huang, Ying
Li, Gen
Hong, Chong
Zheng, Xia
Yu, Haiyang
Zhang, Yan
author_facet Huang, Ying
Li, Gen
Hong, Chong
Zheng, Xia
Yu, Haiyang
Zhang, Yan
author_sort Huang, Ying
collection PubMed
description Steroidal alkaloids contain both steroidal and alkaloid properties in terms of chemical properties and pharmacological activities. Due to outstanding biological activities such as alkaloids and similar pharmacological effects to other steroids, steroidal alkaloids have received special attention in anticancer activity recently. Substituted groups in chemical structure play markedly important roles in biological activities. Therefore, the effective way to obtain lead compounds quickly is structural modification, which is guided by structure–activity relationships (SARs). This review presents the SAR of steroidal alkaloids and anticancer, including pregnane alkaloids, cyclopregnane alkaloids, cholestane alkaloids, C-nor-D-homosteroidal alkaloids, and bis-steroidal pyrazine. A summary of SAR can powerfully help to design and synthesize more lead compounds.
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spelling pubmed-84893812021-10-05 Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships Huang, Ying Li, Gen Hong, Chong Zheng, Xia Yu, Haiyang Zhang, Yan Front Oncol Oncology Steroidal alkaloids contain both steroidal and alkaloid properties in terms of chemical properties and pharmacological activities. Due to outstanding biological activities such as alkaloids and similar pharmacological effects to other steroids, steroidal alkaloids have received special attention in anticancer activity recently. Substituted groups in chemical structure play markedly important roles in biological activities. Therefore, the effective way to obtain lead compounds quickly is structural modification, which is guided by structure–activity relationships (SARs). This review presents the SAR of steroidal alkaloids and anticancer, including pregnane alkaloids, cyclopregnane alkaloids, cholestane alkaloids, C-nor-D-homosteroidal alkaloids, and bis-steroidal pyrazine. A summary of SAR can powerfully help to design and synthesize more lead compounds. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8489381/ /pubmed/34616681 http://dx.doi.org/10.3389/fonc.2021.733369 Text en Copyright © 2021 Huang, Li, Hong, Zheng, Yu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Huang, Ying
Li, Gen
Hong, Chong
Zheng, Xia
Yu, Haiyang
Zhang, Yan
Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships
title Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships
title_full Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships
title_fullStr Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships
title_full_unstemmed Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships
title_short Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure–Activity Relationships
title_sort potential of steroidal alkaloids in cancer: perspective insight into structure–activity relationships
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489381/
https://www.ncbi.nlm.nih.gov/pubmed/34616681
http://dx.doi.org/10.3389/fonc.2021.733369
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