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Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer
BACKGROUND: Inadequate number of lymph nodes examined was not uncommon. We aimed to assess the clinical role of inadequate number of lymph nodes examined in stage II colon cancer. METHODS: The cancer data used in our study were obtained from the SEER (Surveillance, Epidemiology and End Results) prog...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489731/ https://www.ncbi.nlm.nih.gov/pubmed/34616683 http://dx.doi.org/10.3389/fonc.2021.736678 |
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author | Wu, Qi Zhang, Zhiyuan Chen, Yijiao Chang, Jiang Jiang, Yudong Zhu, Dexiang Wei, Ye |
author_facet | Wu, Qi Zhang, Zhiyuan Chen, Yijiao Chang, Jiang Jiang, Yudong Zhu, Dexiang Wei, Ye |
author_sort | Wu, Qi |
collection | PubMed |
description | BACKGROUND: Inadequate number of lymph nodes examined was not uncommon. We aimed to assess the clinical role of inadequate number of lymph nodes examined in stage II colon cancer. METHODS: The cancer data used in our study were obtained from the SEER (Surveillance, Epidemiology and End Results) program. Using the chi-square test, all the variables obtained in our study were compared based on whether patients had enough (≥12) lymph nodes examined. Kaplan–Meier analysis was used for overall survival (OS) analysis, and log-rank test was applied to compare different N stages with the total number of lymph nodes examined. Multivariate analysis was carried out by creating a Cox proportional hazard model to assess the prognostic roles of different variables. RESULTS: In total, 80,296 stage II/III colon cancer patients were recruited for our study. N0 stage with <8 lymph nodes examined would present with a worse prognosis compared to N1 stage (5-year OS rates, 51.6% vs. 57.1%, p < 0.001). Multivariate analyses indicated that OS of N0 stage with <8 lymph nodes examined was similar to that of N1 stage after adjusting for other recognized prognostic factors [hazard ratios (HRs) = 1.051, 95% confidence intervals (CIs) = 1.014–1.090, p = 0.018]. CONCLUSIONS: N0 stage with less than eight lymph nodes examined in stage II colon cancer presented with no better OS compared to that of N1 stage. Stage II colon cancer with less than eight lymph nodes examined needed to be given greater emphasis in clinical practice. |
format | Online Article Text |
id | pubmed-8489731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84897312021-10-05 Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer Wu, Qi Zhang, Zhiyuan Chen, Yijiao Chang, Jiang Jiang, Yudong Zhu, Dexiang Wei, Ye Front Oncol Oncology BACKGROUND: Inadequate number of lymph nodes examined was not uncommon. We aimed to assess the clinical role of inadequate number of lymph nodes examined in stage II colon cancer. METHODS: The cancer data used in our study were obtained from the SEER (Surveillance, Epidemiology and End Results) program. Using the chi-square test, all the variables obtained in our study were compared based on whether patients had enough (≥12) lymph nodes examined. Kaplan–Meier analysis was used for overall survival (OS) analysis, and log-rank test was applied to compare different N stages with the total number of lymph nodes examined. Multivariate analysis was carried out by creating a Cox proportional hazard model to assess the prognostic roles of different variables. RESULTS: In total, 80,296 stage II/III colon cancer patients were recruited for our study. N0 stage with <8 lymph nodes examined would present with a worse prognosis compared to N1 stage (5-year OS rates, 51.6% vs. 57.1%, p < 0.001). Multivariate analyses indicated that OS of N0 stage with <8 lymph nodes examined was similar to that of N1 stage after adjusting for other recognized prognostic factors [hazard ratios (HRs) = 1.051, 95% confidence intervals (CIs) = 1.014–1.090, p = 0.018]. CONCLUSIONS: N0 stage with less than eight lymph nodes examined in stage II colon cancer presented with no better OS compared to that of N1 stage. Stage II colon cancer with less than eight lymph nodes examined needed to be given greater emphasis in clinical practice. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8489731/ /pubmed/34616683 http://dx.doi.org/10.3389/fonc.2021.736678 Text en Copyright © 2021 Wu, Zhang, Chen, Chang, Jiang, Zhu and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wu, Qi Zhang, Zhiyuan Chen, Yijiao Chang, Jiang Jiang, Yudong Zhu, Dexiang Wei, Ye Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer |
title | Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer |
title_full | Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer |
title_fullStr | Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer |
title_full_unstemmed | Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer |
title_short | Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer |
title_sort | impact of inadequate number of lymph nodes examined on survival in stage ii colon cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489731/ https://www.ncbi.nlm.nih.gov/pubmed/34616683 http://dx.doi.org/10.3389/fonc.2021.736678 |
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