Cargando…

Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer

BACKGROUND: Inadequate number of lymph nodes examined was not uncommon. We aimed to assess the clinical role of inadequate number of lymph nodes examined in stage II colon cancer. METHODS: The cancer data used in our study were obtained from the SEER (Surveillance, Epidemiology and End Results) prog...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Qi, Zhang, Zhiyuan, Chen, Yijiao, Chang, Jiang, Jiang, Yudong, Zhu, Dexiang, Wei, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489731/
https://www.ncbi.nlm.nih.gov/pubmed/34616683
http://dx.doi.org/10.3389/fonc.2021.736678
_version_ 1784578385804001280
author Wu, Qi
Zhang, Zhiyuan
Chen, Yijiao
Chang, Jiang
Jiang, Yudong
Zhu, Dexiang
Wei, Ye
author_facet Wu, Qi
Zhang, Zhiyuan
Chen, Yijiao
Chang, Jiang
Jiang, Yudong
Zhu, Dexiang
Wei, Ye
author_sort Wu, Qi
collection PubMed
description BACKGROUND: Inadequate number of lymph nodes examined was not uncommon. We aimed to assess the clinical role of inadequate number of lymph nodes examined in stage II colon cancer. METHODS: The cancer data used in our study were obtained from the SEER (Surveillance, Epidemiology and End Results) program. Using the chi-square test, all the variables obtained in our study were compared based on whether patients had enough (≥12) lymph nodes examined. Kaplan–Meier analysis was used for overall survival (OS) analysis, and log-rank test was applied to compare different N stages with the total number of lymph nodes examined. Multivariate analysis was carried out by creating a Cox proportional hazard model to assess the prognostic roles of different variables. RESULTS: In total, 80,296 stage II/III colon cancer patients were recruited for our study. N0 stage with <8 lymph nodes examined would present with a worse prognosis compared to N1 stage (5-year OS rates, 51.6% vs. 57.1%, p < 0.001). Multivariate analyses indicated that OS of N0 stage with <8 lymph nodes examined was similar to that of N1 stage after adjusting for other recognized prognostic factors [hazard ratios (HRs) = 1.051, 95% confidence intervals (CIs) = 1.014–1.090, p = 0.018]. CONCLUSIONS: N0 stage with less than eight lymph nodes examined in stage II colon cancer presented with no better OS compared to that of N1 stage. Stage II colon cancer with less than eight lymph nodes examined needed to be given greater emphasis in clinical practice.
format Online
Article
Text
id pubmed-8489731
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84897312021-10-05 Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer Wu, Qi Zhang, Zhiyuan Chen, Yijiao Chang, Jiang Jiang, Yudong Zhu, Dexiang Wei, Ye Front Oncol Oncology BACKGROUND: Inadequate number of lymph nodes examined was not uncommon. We aimed to assess the clinical role of inadequate number of lymph nodes examined in stage II colon cancer. METHODS: The cancer data used in our study were obtained from the SEER (Surveillance, Epidemiology and End Results) program. Using the chi-square test, all the variables obtained in our study were compared based on whether patients had enough (≥12) lymph nodes examined. Kaplan–Meier analysis was used for overall survival (OS) analysis, and log-rank test was applied to compare different N stages with the total number of lymph nodes examined. Multivariate analysis was carried out by creating a Cox proportional hazard model to assess the prognostic roles of different variables. RESULTS: In total, 80,296 stage II/III colon cancer patients were recruited for our study. N0 stage with <8 lymph nodes examined would present with a worse prognosis compared to N1 stage (5-year OS rates, 51.6% vs. 57.1%, p < 0.001). Multivariate analyses indicated that OS of N0 stage with <8 lymph nodes examined was similar to that of N1 stage after adjusting for other recognized prognostic factors [hazard ratios (HRs) = 1.051, 95% confidence intervals (CIs) = 1.014–1.090, p = 0.018]. CONCLUSIONS: N0 stage with less than eight lymph nodes examined in stage II colon cancer presented with no better OS compared to that of N1 stage. Stage II colon cancer with less than eight lymph nodes examined needed to be given greater emphasis in clinical practice. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8489731/ /pubmed/34616683 http://dx.doi.org/10.3389/fonc.2021.736678 Text en Copyright © 2021 Wu, Zhang, Chen, Chang, Jiang, Zhu and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Qi
Zhang, Zhiyuan
Chen, Yijiao
Chang, Jiang
Jiang, Yudong
Zhu, Dexiang
Wei, Ye
Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer
title Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer
title_full Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer
title_fullStr Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer
title_full_unstemmed Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer
title_short Impact of Inadequate Number of Lymph Nodes Examined on Survival in Stage II Colon Cancer
title_sort impact of inadequate number of lymph nodes examined on survival in stage ii colon cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489731/
https://www.ncbi.nlm.nih.gov/pubmed/34616683
http://dx.doi.org/10.3389/fonc.2021.736678
work_keys_str_mv AT wuqi impactofinadequatenumberoflymphnodesexaminedonsurvivalinstageiicoloncancer
AT zhangzhiyuan impactofinadequatenumberoflymphnodesexaminedonsurvivalinstageiicoloncancer
AT chenyijiao impactofinadequatenumberoflymphnodesexaminedonsurvivalinstageiicoloncancer
AT changjiang impactofinadequatenumberoflymphnodesexaminedonsurvivalinstageiicoloncancer
AT jiangyudong impactofinadequatenumberoflymphnodesexaminedonsurvivalinstageiicoloncancer
AT zhudexiang impactofinadequatenumberoflymphnodesexaminedonsurvivalinstageiicoloncancer
AT weiye impactofinadequatenumberoflymphnodesexaminedonsurvivalinstageiicoloncancer