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Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall
OBJECTIVES: Chronic venous disease (CVeD) is a multifactorial and debilitating condition that has a high prevalence in Western countries and an important associated socioeconomic burden. Varicose veins (VVs) are the most common manifestations of CVeD. Pathologically, many morphological and functiona...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489764/ https://www.ncbi.nlm.nih.gov/pubmed/34590920 http://dx.doi.org/10.1177/03000605211041275 |
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author | Ortega, Miguel A Fraile-Martínez, Oscar García-Montero, Cielo Ruiz-Grande, Fernando Barrena, Silve Montoya, Hector Pekarek, Leonel Zoullas, Sofia Alvarez-Mon, Miguel A Sainz, Felipe Asúnsolo, Angel Acero, Julio Álvarez-Mon, Melchor Buján, Julia García-Honduvilla, Natalio Guijarro, Luis G |
author_facet | Ortega, Miguel A Fraile-Martínez, Oscar García-Montero, Cielo Ruiz-Grande, Fernando Barrena, Silve Montoya, Hector Pekarek, Leonel Zoullas, Sofia Alvarez-Mon, Miguel A Sainz, Felipe Asúnsolo, Angel Acero, Julio Álvarez-Mon, Melchor Buján, Julia García-Honduvilla, Natalio Guijarro, Luis G |
author_sort | Ortega, Miguel A |
collection | PubMed |
description | OBJECTIVES: Chronic venous disease (CVeD) is a multifactorial and debilitating condition that has a high prevalence in Western countries and an important associated socioeconomic burden. Varicose veins (VVs) are the most common manifestations of CVeD. Pathologically, many morphological and functional changes have been described in VVs, which most notably affect venous wall integrity. Previous studies have found several molecular alterations that negatively affect normal cell signaling pathways. Insulin receptor substrate (IRS)-4 is a central adaptor protein that is closely related to insulin/insulin-like growth factor-1 signaling upstream, phosphatidylinositol 3-kinase/Akt or mitogen-activated protein kinases downstream, and other proteins. These molecular pathways have been implicated in CVeD pathogenesis. Thus, the aim of our study was to identify the role of IRS-4 in VV tissue. METHODS: We conducted a histopathological study to analyze IRS-4 protein expression in CVeD patients compared with healthy controls. RESULTS: Our results demonstrate a significant increase in IRS-4 expression in VV tissue. CONCLUSIONS: IRS-4 may be implicated in CVeD development and progression. Therefore, IRS-4 could be a potential diagnostic or therapeutic target for patients with this condition. |
format | Online Article Text |
id | pubmed-8489764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-84897642021-10-05 Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall Ortega, Miguel A Fraile-Martínez, Oscar García-Montero, Cielo Ruiz-Grande, Fernando Barrena, Silve Montoya, Hector Pekarek, Leonel Zoullas, Sofia Alvarez-Mon, Miguel A Sainz, Felipe Asúnsolo, Angel Acero, Julio Álvarez-Mon, Melchor Buján, Julia García-Honduvilla, Natalio Guijarro, Luis G J Int Med Res Pre-Clinical Research Report OBJECTIVES: Chronic venous disease (CVeD) is a multifactorial and debilitating condition that has a high prevalence in Western countries and an important associated socioeconomic burden. Varicose veins (VVs) are the most common manifestations of CVeD. Pathologically, many morphological and functional changes have been described in VVs, which most notably affect venous wall integrity. Previous studies have found several molecular alterations that negatively affect normal cell signaling pathways. Insulin receptor substrate (IRS)-4 is a central adaptor protein that is closely related to insulin/insulin-like growth factor-1 signaling upstream, phosphatidylinositol 3-kinase/Akt or mitogen-activated protein kinases downstream, and other proteins. These molecular pathways have been implicated in CVeD pathogenesis. Thus, the aim of our study was to identify the role of IRS-4 in VV tissue. METHODS: We conducted a histopathological study to analyze IRS-4 protein expression in CVeD patients compared with healthy controls. RESULTS: Our results demonstrate a significant increase in IRS-4 expression in VV tissue. CONCLUSIONS: IRS-4 may be implicated in CVeD development and progression. Therefore, IRS-4 could be a potential diagnostic or therapeutic target for patients with this condition. SAGE Publications 2021-09-30 /pmc/articles/PMC8489764/ /pubmed/34590920 http://dx.doi.org/10.1177/03000605211041275 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Pre-Clinical Research Report Ortega, Miguel A Fraile-Martínez, Oscar García-Montero, Cielo Ruiz-Grande, Fernando Barrena, Silve Montoya, Hector Pekarek, Leonel Zoullas, Sofia Alvarez-Mon, Miguel A Sainz, Felipe Asúnsolo, Angel Acero, Julio Álvarez-Mon, Melchor Buján, Julia García-Honduvilla, Natalio Guijarro, Luis G Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall |
title | Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall |
title_full | Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall |
title_fullStr | Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall |
title_full_unstemmed | Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall |
title_short | Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall |
title_sort | chronic venous disease patients show increased irs-4 expression in the great saphenous vein wall |
topic | Pre-Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489764/ https://www.ncbi.nlm.nih.gov/pubmed/34590920 http://dx.doi.org/10.1177/03000605211041275 |
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