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Genomic Insight Into the Population Structure and Admixture History of Tai-Kadai-Speaking Sui People in Southwest China

Sui people, which belong to the Tai-Kadai-speaking family, remain poorly characterized due to a lack of genome-wide data. To infer the fine-scale population genetic structure and putative genetic sources of the Sui people, we genotyped 498,655 genome-wide single-nucleotide polymorphisms (SNPs) using...

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Autores principales: Bin, Xiaoyun, Wang, Rui, Huang, Youyi, Wei, Rongyao, Zhu, Kongyang, Yang, Xiaomin, Ma, Hao, He, Guanglin, Guo, Jianxin, Zhao, Jing, Yang, Meiqing, Chen, Jing, Zhang, Xianpeng, Tao, Le, Liu, Yilan, Huang, Xiufeng, Wang, Chuan-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489805/
https://www.ncbi.nlm.nih.gov/pubmed/34616433
http://dx.doi.org/10.3389/fgene.2021.735084
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author Bin, Xiaoyun
Wang, Rui
Huang, Youyi
Wei, Rongyao
Zhu, Kongyang
Yang, Xiaomin
Ma, Hao
He, Guanglin
Guo, Jianxin
Zhao, Jing
Yang, Meiqing
Chen, Jing
Zhang, Xianpeng
Tao, Le
Liu, Yilan
Huang, Xiufeng
Wang, Chuan-Chao
author_facet Bin, Xiaoyun
Wang, Rui
Huang, Youyi
Wei, Rongyao
Zhu, Kongyang
Yang, Xiaomin
Ma, Hao
He, Guanglin
Guo, Jianxin
Zhao, Jing
Yang, Meiqing
Chen, Jing
Zhang, Xianpeng
Tao, Le
Liu, Yilan
Huang, Xiufeng
Wang, Chuan-Chao
author_sort Bin, Xiaoyun
collection PubMed
description Sui people, which belong to the Tai-Kadai-speaking family, remain poorly characterized due to a lack of genome-wide data. To infer the fine-scale population genetic structure and putative genetic sources of the Sui people, we genotyped 498,655 genome-wide single-nucleotide polymorphisms (SNPs) using SNP arrays in 68 Sui individuals from seven indigenous populations in Guizhou province and Guangxi Zhuang Autonomous Region in Southwest China and co-analyzed with available East Asians via a series of population genetic methods including principal component analysis (PCA), ADMIXTURE, pairwise Fst genetic distance, f-statistics, qpWave, and qpAdm. Our results revealed that Guangxi and Guizhou Sui people showed a strong genetic affinity with populations from southern China and Southeast Asia, especially Tai-Kadai- and Hmong-Mien-speaking populations as well as ancient Iron Age Taiwan Hanben, Gongguan individuals supporting the hypothesis that Sui people came from southern China originally. The indigenous Tai-Kadai-related ancestry (represented by Li), Northern East Asian-related ancestry, and Hmong-Mien-related lineage contributed to the formation processes of the Sui people. We identified the genetic substructure within Sui groups: Guizhou Sui people were relatively homogeneous and possessed similar genetic profiles with neighboring Tai-Kadai-related populations, such as Maonan. While Sui people in Yizhou and Huanjiang of Guangxi might receive unique, additional gene flow from Hmong-Mien-speaking populations and Northern East Asians, respectively, after the divergence within other Sui populations. Sui people could be modeled as the admixture of ancient Yellow River Basin farmer-related ancestry (36.2–54.7%) and ancient coastal Southeast Asian-related ancestry (45.3–63.8%). We also identified the potential positive selection signals related to the disease susceptibility in Sui people via integrated haplotype score (iHS) and number of segregating sites by length (nSL) scores. These genomic findings provided new insights into the demographic history of Tai-Kadai-speaking Sui people and their interaction with neighboring populations in Southern China.
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spelling pubmed-84898052021-10-05 Genomic Insight Into the Population Structure and Admixture History of Tai-Kadai-Speaking Sui People in Southwest China Bin, Xiaoyun Wang, Rui Huang, Youyi Wei, Rongyao Zhu, Kongyang Yang, Xiaomin Ma, Hao He, Guanglin Guo, Jianxin Zhao, Jing Yang, Meiqing Chen, Jing Zhang, Xianpeng Tao, Le Liu, Yilan Huang, Xiufeng Wang, Chuan-Chao Front Genet Genetics Sui people, which belong to the Tai-Kadai-speaking family, remain poorly characterized due to a lack of genome-wide data. To infer the fine-scale population genetic structure and putative genetic sources of the Sui people, we genotyped 498,655 genome-wide single-nucleotide polymorphisms (SNPs) using SNP arrays in 68 Sui individuals from seven indigenous populations in Guizhou province and Guangxi Zhuang Autonomous Region in Southwest China and co-analyzed with available East Asians via a series of population genetic methods including principal component analysis (PCA), ADMIXTURE, pairwise Fst genetic distance, f-statistics, qpWave, and qpAdm. Our results revealed that Guangxi and Guizhou Sui people showed a strong genetic affinity with populations from southern China and Southeast Asia, especially Tai-Kadai- and Hmong-Mien-speaking populations as well as ancient Iron Age Taiwan Hanben, Gongguan individuals supporting the hypothesis that Sui people came from southern China originally. The indigenous Tai-Kadai-related ancestry (represented by Li), Northern East Asian-related ancestry, and Hmong-Mien-related lineage contributed to the formation processes of the Sui people. We identified the genetic substructure within Sui groups: Guizhou Sui people were relatively homogeneous and possessed similar genetic profiles with neighboring Tai-Kadai-related populations, such as Maonan. While Sui people in Yizhou and Huanjiang of Guangxi might receive unique, additional gene flow from Hmong-Mien-speaking populations and Northern East Asians, respectively, after the divergence within other Sui populations. Sui people could be modeled as the admixture of ancient Yellow River Basin farmer-related ancestry (36.2–54.7%) and ancient coastal Southeast Asian-related ancestry (45.3–63.8%). We also identified the potential positive selection signals related to the disease susceptibility in Sui people via integrated haplotype score (iHS) and number of segregating sites by length (nSL) scores. These genomic findings provided new insights into the demographic history of Tai-Kadai-speaking Sui people and their interaction with neighboring populations in Southern China. Frontiers Media S.A. 2021-09-20 /pmc/articles/PMC8489805/ /pubmed/34616433 http://dx.doi.org/10.3389/fgene.2021.735084 Text en Copyright © 2021 Bin, Wang, Huang, Wei, Zhu, Yang, Ma, He, Guo, Zhao, Yang, Chen, Zhang, Tao, Liu, Huang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Bin, Xiaoyun
Wang, Rui
Huang, Youyi
Wei, Rongyao
Zhu, Kongyang
Yang, Xiaomin
Ma, Hao
He, Guanglin
Guo, Jianxin
Zhao, Jing
Yang, Meiqing
Chen, Jing
Zhang, Xianpeng
Tao, Le
Liu, Yilan
Huang, Xiufeng
Wang, Chuan-Chao
Genomic Insight Into the Population Structure and Admixture History of Tai-Kadai-Speaking Sui People in Southwest China
title Genomic Insight Into the Population Structure and Admixture History of Tai-Kadai-Speaking Sui People in Southwest China
title_full Genomic Insight Into the Population Structure and Admixture History of Tai-Kadai-Speaking Sui People in Southwest China
title_fullStr Genomic Insight Into the Population Structure and Admixture History of Tai-Kadai-Speaking Sui People in Southwest China
title_full_unstemmed Genomic Insight Into the Population Structure and Admixture History of Tai-Kadai-Speaking Sui People in Southwest China
title_short Genomic Insight Into the Population Structure and Admixture History of Tai-Kadai-Speaking Sui People in Southwest China
title_sort genomic insight into the population structure and admixture history of tai-kadai-speaking sui people in southwest china
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489805/
https://www.ncbi.nlm.nih.gov/pubmed/34616433
http://dx.doi.org/10.3389/fgene.2021.735084
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