COVID-19 and metabolic disease: mechanisms and clinical management

Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver diseas...

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Detalles Bibliográficos
Autores principales: Steenblock, Charlotte, Schwarz, Peter E H, Ludwig, Barbara, Linkermann, Andreas, Zimmet, Paul, Kulebyakin, Konstantin, Tkachuk, Vsevolod A, Markov, Alexander G, Lehnert, Hendrik, de Angelis, Martin Hrabě, Rietzsch, Hannes, Rodionov, Roman N, Khunti, Kamlesh, Hopkins, David, Birkenfeld, Andreas L, Boehm, Bernhard, Holt, Richard I G, Skyler, Jay S, DeVries, J Hans, Renard, Eric, Eckel, Robert H, Alberti, K George M M, Geloneze, Bruno, Chan, Juliana C, Mbanya, Jean Claude, Onyegbutulem, Henry C, Ramachandran, Ambady, Basit, Abdul, Hassanein, Mohamed, Bewick, Gavin, Spinas, Giatgen A, Beuschlein, Felix, Landgraf, Rüdiger, Rubino, Francesco, Mingrone, Geltrude, Bornstein, Stefan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489878/
https://www.ncbi.nlm.nih.gov/pubmed/34619105
http://dx.doi.org/10.1016/S2213-8587(21)00244-8
Descripción
Sumario:Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.

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