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The claudin–transcription factor signaling pathway

Claudins (CLDNs) represent major transmembrane proteins of tight junctions and contribute to the barrier function. They also serve as anchors for several signaling proteins, but the underlying molecular basis has yet to be established. The present review covers the recent progress in our understandi...

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Detalles Bibliográficos
Autores principales: Sugimoto, Kotaro, Chiba, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489944/
https://www.ncbi.nlm.nih.gov/pubmed/33906582
http://dx.doi.org/10.1080/21688370.2021.1908109
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author Sugimoto, Kotaro
Chiba, Hideki
author_facet Sugimoto, Kotaro
Chiba, Hideki
author_sort Sugimoto, Kotaro
collection PubMed
description Claudins (CLDNs) represent major transmembrane proteins of tight junctions and contribute to the barrier function. They also serve as anchors for several signaling proteins, but the underlying molecular basis has yet to be established. The present review covers the recent progress in our understanding of the CLDN signaling pathway in health and disease. We discuss the functional relevance of phosphotyrosine motifs in the C-terminal cytoplasmic domain of CLDNs and define mutual regulation between CLDNs and Src-family kinases (SFKs). In addition, we focus on the crosstalk between CLDN and transcription factor signaling. We also describe how aberrant CLDN–transcription factor signaling promotes or inhibits cancer progression. We propose that a link between various cell adhesion molecules and transcription factors coordinates a range of physiological and pathological events via activation or suppression of target genes.
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spelling pubmed-84899442021-10-05 The claudin–transcription factor signaling pathway Sugimoto, Kotaro Chiba, Hideki Tissue Barriers Review Claudins (CLDNs) represent major transmembrane proteins of tight junctions and contribute to the barrier function. They also serve as anchors for several signaling proteins, but the underlying molecular basis has yet to be established. The present review covers the recent progress in our understanding of the CLDN signaling pathway in health and disease. We discuss the functional relevance of phosphotyrosine motifs in the C-terminal cytoplasmic domain of CLDNs and define mutual regulation between CLDNs and Src-family kinases (SFKs). In addition, we focus on the crosstalk between CLDN and transcription factor signaling. We also describe how aberrant CLDN–transcription factor signaling promotes or inhibits cancer progression. We propose that a link between various cell adhesion molecules and transcription factors coordinates a range of physiological and pathological events via activation or suppression of target genes. Taylor & Francis 2021-04-27 /pmc/articles/PMC8489944/ /pubmed/33906582 http://dx.doi.org/10.1080/21688370.2021.1908109 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sugimoto, Kotaro
Chiba, Hideki
The claudin–transcription factor signaling pathway
title The claudin–transcription factor signaling pathway
title_full The claudin–transcription factor signaling pathway
title_fullStr The claudin–transcription factor signaling pathway
title_full_unstemmed The claudin–transcription factor signaling pathway
title_short The claudin–transcription factor signaling pathway
title_sort claudin–transcription factor signaling pathway
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489944/
https://www.ncbi.nlm.nih.gov/pubmed/33906582
http://dx.doi.org/10.1080/21688370.2021.1908109
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