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The claudin–transcription factor signaling pathway
Claudins (CLDNs) represent major transmembrane proteins of tight junctions and contribute to the barrier function. They also serve as anchors for several signaling proteins, but the underlying molecular basis has yet to be established. The present review covers the recent progress in our understandi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489944/ https://www.ncbi.nlm.nih.gov/pubmed/33906582 http://dx.doi.org/10.1080/21688370.2021.1908109 |
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author | Sugimoto, Kotaro Chiba, Hideki |
author_facet | Sugimoto, Kotaro Chiba, Hideki |
author_sort | Sugimoto, Kotaro |
collection | PubMed |
description | Claudins (CLDNs) represent major transmembrane proteins of tight junctions and contribute to the barrier function. They also serve as anchors for several signaling proteins, but the underlying molecular basis has yet to be established. The present review covers the recent progress in our understanding of the CLDN signaling pathway in health and disease. We discuss the functional relevance of phosphotyrosine motifs in the C-terminal cytoplasmic domain of CLDNs and define mutual regulation between CLDNs and Src-family kinases (SFKs). In addition, we focus on the crosstalk between CLDN and transcription factor signaling. We also describe how aberrant CLDN–transcription factor signaling promotes or inhibits cancer progression. We propose that a link between various cell adhesion molecules and transcription factors coordinates a range of physiological and pathological events via activation or suppression of target genes. |
format | Online Article Text |
id | pubmed-8489944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-84899442021-10-05 The claudin–transcription factor signaling pathway Sugimoto, Kotaro Chiba, Hideki Tissue Barriers Review Claudins (CLDNs) represent major transmembrane proteins of tight junctions and contribute to the barrier function. They also serve as anchors for several signaling proteins, but the underlying molecular basis has yet to be established. The present review covers the recent progress in our understanding of the CLDN signaling pathway in health and disease. We discuss the functional relevance of phosphotyrosine motifs in the C-terminal cytoplasmic domain of CLDNs and define mutual regulation between CLDNs and Src-family kinases (SFKs). In addition, we focus on the crosstalk between CLDN and transcription factor signaling. We also describe how aberrant CLDN–transcription factor signaling promotes or inhibits cancer progression. We propose that a link between various cell adhesion molecules and transcription factors coordinates a range of physiological and pathological events via activation or suppression of target genes. Taylor & Francis 2021-04-27 /pmc/articles/PMC8489944/ /pubmed/33906582 http://dx.doi.org/10.1080/21688370.2021.1908109 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Sugimoto, Kotaro Chiba, Hideki The claudin–transcription factor signaling pathway |
title | The claudin–transcription factor signaling pathway |
title_full | The claudin–transcription factor signaling pathway |
title_fullStr | The claudin–transcription factor signaling pathway |
title_full_unstemmed | The claudin–transcription factor signaling pathway |
title_short | The claudin–transcription factor signaling pathway |
title_sort | claudin–transcription factor signaling pathway |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489944/ https://www.ncbi.nlm.nih.gov/pubmed/33906582 http://dx.doi.org/10.1080/21688370.2021.1908109 |
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