TFG: a novel regulator of ULK1-dependent autophagy

TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated prote...

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Autores principales: Cecconi, Francesco, Nazio, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489955/
https://www.ncbi.nlm.nih.gov/pubmed/34616872
http://dx.doi.org/10.1080/23723556.2021.1945895
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author Cecconi, Francesco
Nazio, Francesca
author_facet Cecconi, Francesco
Nazio, Francesca
author_sort Cecconi, Francesco
collection PubMed
description TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases.
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spelling pubmed-84899552021-10-05 TFG: a novel regulator of ULK1-dependent autophagy Cecconi, Francesco Nazio, Francesca Mol Cell Oncol Author’s Views TRK-fused gene (TFG) is a protein implicated in multiple neurodegenerative diseases and oncogenesis. We have recently shown that, under starvation conditions, TFG contributes to spatial control of autophagy by facilitating Unc-51 like autophagy activating kinase 1 (ULK1)-microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) interaction to modulate omegasome and autophagosome formation. Defective TFG-mediated autophagy could thus be postulated as a possible contributor to ontogenesis or progression of TFG-related diseases. Taylor & Francis 2021-07-12 /pmc/articles/PMC8489955/ /pubmed/34616872 http://dx.doi.org/10.1080/23723556.2021.1945895 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Cecconi, Francesco
Nazio, Francesca
TFG: a novel regulator of ULK1-dependent autophagy
title TFG: a novel regulator of ULK1-dependent autophagy
title_full TFG: a novel regulator of ULK1-dependent autophagy
title_fullStr TFG: a novel regulator of ULK1-dependent autophagy
title_full_unstemmed TFG: a novel regulator of ULK1-dependent autophagy
title_short TFG: a novel regulator of ULK1-dependent autophagy
title_sort tfg: a novel regulator of ulk1-dependent autophagy
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489955/
https://www.ncbi.nlm.nih.gov/pubmed/34616872
http://dx.doi.org/10.1080/23723556.2021.1945895
work_keys_str_mv AT cecconifrancesco tfganovelregulatorofulk1dependentautophagy
AT naziofrancesca tfganovelregulatorofulk1dependentautophagy

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