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Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration

The potential to differentiate into different cell lines, added to the easy and cost-effective method of extraction, makes adipose-derived stem cells (ADSCs) an object of interest in lymphedema treatment. Our study’s goal was to conduct a comprehensive systematic review of the use of ADSCs in lympha...

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Autores principales: Forte, Antonio Jorge, Boczar, Daniel, Sarabia-Estrada, Rachel, Huayllani, Maria T., Avila, Francisco R., Torres, Ricardo A., Guliyeva, Gunel, Aung, Thiha, Quiñones-Hinojosa, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Plastic and Reconstructive Surgeons 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490113/
https://www.ncbi.nlm.nih.gov/pubmed/34583446
http://dx.doi.org/10.5999/aps.2021.00339
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author Forte, Antonio Jorge
Boczar, Daniel
Sarabia-Estrada, Rachel
Huayllani, Maria T.
Avila, Francisco R.
Torres, Ricardo A.
Guliyeva, Gunel
Aung, Thiha
Quiñones-Hinojosa, Alfredo
author_facet Forte, Antonio Jorge
Boczar, Daniel
Sarabia-Estrada, Rachel
Huayllani, Maria T.
Avila, Francisco R.
Torres, Ricardo A.
Guliyeva, Gunel
Aung, Thiha
Quiñones-Hinojosa, Alfredo
author_sort Forte, Antonio Jorge
collection PubMed
description The potential to differentiate into different cell lines, added to the easy and cost-effective method of extraction, makes adipose-derived stem cells (ADSCs) an object of interest in lymphedema treatment. Our study’s goal was to conduct a comprehensive systematic review of the use of ADSCs in lymphatic tissue engineering and regeneration. On July 23, 2019, using PubMed/MEDLINE, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, and Embase databases, we conducted a systematic review of published literature on the use of ADSCs in lymphatic tissue engineering and regeneration. There were no language or time frame limitations, and the following search strategy was applied: ((Adipose stem cell) OR Adipose-derived stem cell)) AND ((Lymphedema) OR Breast Cancer Lymphedema). Only original research manuscripts were included. Fourteen studies fulfilled the inclusion criteria. Eleven studies were experimental (in vitro or in vivo in animals), and only three were clinical. Publications on the topic demonstrated that ADSCs promote lymphangiogenesis, and its effect could be enhanced by modulation of vascular endothelial growth factor-C, interleukin-7, prospero homeobox protein 1, and transforming growth factor-β1. Pilot clinical studies included 11 patients with breast cancer-related lymphedema, and no significant side effects were present at 12-month follow-up. Literature on the use of ADSCs in lymphatic tissue engineering and regeneration demonstrated promising data. Clinical evidence is still in its infancy, but the scientific community agrees that ADSCs can be useful in regenerative lymphangiogenesis. Data collected in this review indicate that unprecedented advances in lymphedema treatment can be anticipated in the upcoming years.
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spelling pubmed-84901132021-10-08 Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration Forte, Antonio Jorge Boczar, Daniel Sarabia-Estrada, Rachel Huayllani, Maria T. Avila, Francisco R. Torres, Ricardo A. Guliyeva, Gunel Aung, Thiha Quiñones-Hinojosa, Alfredo Arch Plast Surg Research/Experimental The potential to differentiate into different cell lines, added to the easy and cost-effective method of extraction, makes adipose-derived stem cells (ADSCs) an object of interest in lymphedema treatment. Our study’s goal was to conduct a comprehensive systematic review of the use of ADSCs in lymphatic tissue engineering and regeneration. On July 23, 2019, using PubMed/MEDLINE, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, and Embase databases, we conducted a systematic review of published literature on the use of ADSCs in lymphatic tissue engineering and regeneration. There were no language or time frame limitations, and the following search strategy was applied: ((Adipose stem cell) OR Adipose-derived stem cell)) AND ((Lymphedema) OR Breast Cancer Lymphedema). Only original research manuscripts were included. Fourteen studies fulfilled the inclusion criteria. Eleven studies were experimental (in vitro or in vivo in animals), and only three were clinical. Publications on the topic demonstrated that ADSCs promote lymphangiogenesis, and its effect could be enhanced by modulation of vascular endothelial growth factor-C, interleukin-7, prospero homeobox protein 1, and transforming growth factor-β1. Pilot clinical studies included 11 patients with breast cancer-related lymphedema, and no significant side effects were present at 12-month follow-up. Literature on the use of ADSCs in lymphatic tissue engineering and regeneration demonstrated promising data. Clinical evidence is still in its infancy, but the scientific community agrees that ADSCs can be useful in regenerative lymphangiogenesis. Data collected in this review indicate that unprecedented advances in lymphedema treatment can be anticipated in the upcoming years. Korean Society of Plastic and Reconstructive Surgeons 2021-09 2021-09-15 /pmc/articles/PMC8490113/ /pubmed/34583446 http://dx.doi.org/10.5999/aps.2021.00339 Text en Copyright © 2021 The Korean Society of Plastic and Reconstructive Surgeons https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research/Experimental
Forte, Antonio Jorge
Boczar, Daniel
Sarabia-Estrada, Rachel
Huayllani, Maria T.
Avila, Francisco R.
Torres, Ricardo A.
Guliyeva, Gunel
Aung, Thiha
Quiñones-Hinojosa, Alfredo
Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration
title Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration
title_full Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration
title_fullStr Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration
title_full_unstemmed Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration
title_short Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration
title_sort use of adipose-derived stem cells in lymphatic tissue engineering and regeneration
topic Research/Experimental
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490113/
https://www.ncbi.nlm.nih.gov/pubmed/34583446
http://dx.doi.org/10.5999/aps.2021.00339
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