Cargando…

Metabolic Perturbation Associated With COVID-19 Disease Severity and SARS-CoV-2 Replication

Viruses hijack host metabolic pathways for their replicative advantage. In this study, using patient-derived multiomics data and in vitro infection assays, we aimed to understand the role of key metabolic pathways that can regulate severe acute respiratory syndrome coronavirus-2 reproduction and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krishnan, Shuba, Nordqvist, Hampus, Ambikan, Anoop T., Gupta, Soham, Sperk, Maike, Svensson-Akusjärvi, Sara, Mikaeloff, Flora, Benfeitas, Rui, Saccon, Elisa, Ponnan, Sivasankaran Munusamy, Rodriguez, Jimmy Esneider, Nikouyan, Negin, Odeh, Amani, Ahlén, Gustaf, Asghar, Muhammad, Sällberg, Matti, Vesterbacka, Jan, Nowak, Piotr, Végvári, Ákos, Sönnerborg, Anders, Treutiger, Carl Johan, Neogi, Ujjwal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490130/ https://www.ncbi.nlm.nih.gov/pubmed/34619366 http://dx.doi.org/10.1016/j.mcpro.2021.100159

Ejemplares similares

Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status
por: Sperk, Maike, et al.
Publicado: (2021)

Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity
por: Ambikan, Anoop T., et al.
Publicado: (2022)

Role of myeloid cells in system-level immunometabolic dysregulation during prolonged successful HIV-1 treatment
por: Svensson Akusjärvi, Sara, et al.
Publicado: (2023)

Integrative proteo-transcriptomic and immunophenotyping signatures of HIV-1 elite control phenotype: A cross-talk between glycolysis and HIF signaling
por: Akusjärvi, Sara Svensson, et al.
Publicado: (2021)

Genome-scale metabolic models for natural and long-term drug-induced viral control in HIV infection
por: Ambikan, Anoop T, et al.
Publicado: (2022)

Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells
por: Appelberg, Sofia, et al.
Publicado: (2020)

Peripheral blood CD4(+)CCR6(+) compartment differentiates HIV-1 infected or seropositive elite controllers from long-term successfully treated individuals
por: Svensson Akusjärvi, Sara, et al.
Publicado: (2022)

Utility of Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses
por: Sperk, Maike, et al.
Publicado: (2020)

Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2
por: Saccon, Elisa, et al.
Publicado: (2021)

Cytotoxic Lymphocytes Target HIV-1 Gag Through Granzyme M-Mediated Cleavage
por: Saccon, Elisa, et al.
Publicado: (2021)

Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells
por: Chen, Xi, et al.
Publicado: (2021)

The central role of the glutamate metabolism in long-term antiretroviral treated HIV-infected individuals with metabolic syndrome
por: Gelpi, Marco, et al.
Publicado: (2021)

Trans cohort metabolic reprogramming towards glutaminolysis in long-term successfully treated HIV-infection
por: Mikaeloff, Flora, et al.
Publicado: (2022)

Nucleoside-Modified mRNA Vaccines Protect IFNAR(–/–) Mice against Crimean-Congo Hemorrhagic Fever Virus Infection
por: Appelberg, Sofia, et al.
Publicado: (2022)

Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection
por: Ambikan, Anoop T., et al.
Publicado: (2023)

Multi-omics insights into host-viral response and pathogenesis in Crimean-Congo hemorrhagic fever viruses for novel therapeutic target
por: Neogi, Ujjwal, et al.
Publicado: (2022)

Transcriptomics and Targeted Proteomics Analysis to Gain Insights Into the Immune-control Mechanisms of HIV-1 Infected Elite Controllers
por: Zhang, Wang, et al.
Publicado: (2017)

Characterization of Inducible Transcription and Translation-Competent HIV-1 Using the RNAscope ISH Technology at a Single-Cell Resolution
por: Zhang, Wang, et al.
Publicado: (2018)

Increased acquired protease inhibitor drug resistance mutations in minor HIV-1 quasispecies from infected patients suspected of failing on national second-line therapy in South Africa
por: Obasa, Adetayo Emmanuel, et al.
Publicado: (2021)

Coordinated pyruvate kinase activity is crucial for metabolic adaptation and cell survival during mitochondrial dysfunction
por: Zhou, Xiaoshan, et al.
Publicado: (2021)

Biological Aging in People Living with HIV on Successful Antiretroviral Therapy: Do They Age Faster?
por: Akusjärvi, Sara Svensson, et al.
Publicado: (2023)

Deciphering the Role of Mucosal Immune Responses and the Cervicovaginal Microbiome in Resistance to HIV Infection in HIV-Exposed Seronegative (HESN) Women
por: Munusamy Ponnan, Sivasankaran, et al.
Publicado: (2021)

Proteomic landscape of astrocytes and pericytes infected with HIV/SARS-CoV-2 mono/co-infection, impacting on neurological complications
por: Acharya, Arpan, et al.
Publicado: (2023)

MiDRMpol: A High-Throughput Multiplexed Amplicon Sequencing Workflow to Quantify HIV-1 Drug Resistance Mutations against Protease, Reverse Transcriptase, and Integrase Inhibitors
por: Aralaguppe, Shambhu G., et al.
Publicado: (2019)

Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy
por: Babu, Hemalatha, et al.
Publicado: (2019)

Plasma Metabolic Signature and Abnormalities in HIV-Infected Individuals on Long-Term Successful Antiretroviral Therapy
por: Babu, Hemalatha, et al.
Publicado: (2019)

Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs
por: Neogi, Ujjwal, et al.
Publicado: (2020)

Immune Checkpoints as the Immune System Regulators and Potential Biomarkers in HIV-1 Infection
por: Sperk, Maike, et al.
Publicado: (2018)

In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesis
por: Tiwari, Ritudhwaj, et al.
Publicado: (2020)

Editorial: HBV—the naked truth?
por: Pasetto, Anna, et al.
Publicado: (2019)

Elevated Numbers of HIV-Specific Poly-Functional CD8(+) T Cells With Stem Cell-Like and Follicular Homing Phenotypes in HIV-Exposed Seronegative Individuals
por: Munusamy Ponnan, Sivasankaran, et al.
Publicado: (2021)

Plasma soluble factor following two decades prolonged suppressive antiretroviral therapy in HIV-1-positive males: A cross-sectional study
por: Sperk, Maike, et al.
Publicado: (2018)

Following the path: Increasing trends of HIV-1 drug resistance in China
por: Gupta, Soham, et al.
Publicado: (2020)

The SARS-CoV-2 N Protein Is a Good Component in a Vaccine
por: Ahlén, Gustaf, et al.
Publicado: (2020)

Role of Circulating T Follicular Helper Cells and Stem-Like Memory CD4(+) T Cells in the Pathogenesis of HIV-2 Infection and Disease Progression
por: Ponnan, Sivasankaran Munusamy, et al.
Publicado: (2021)

Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection
por: Mikaeloff, Flora, et al.
Publicado: (2023)

Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers
por: Vesterbacka, Jan, et al.
Publicado: (2017)

Whole-Genome Metagenomic Analysis of the Gut Microbiome in HIV-1-Infected Individuals on Antiretroviral Therapy
por: Bai, Xiangning, et al.
Publicado: (2021)

Functional Aspects of Intrahepatic Hepatitis B Virus-specific T Cells Induced by Therapeutic DNA Vaccination
por: Brass, Anette, et al.
Publicado: (2015)

Publisher Correction: In vitro replicative fitness of early Transmitted founder HIV-1 variants and sensitivity to Interferon alpha
por: Ashokkumar, Manickam, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d4ng3f0v9o7pvk7kml34fl0vg5