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The feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study
PURPOSE: To assess feasibility of conducting acute sarcopenia research in complex populations of hospitalised older adults. METHODS: Patients ≥ 70 years old were recruited to three cohorts: elective colorectal surgery, emergency (abdominal) surgery, medical patients with infections. Participants wer...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490139/ https://www.ncbi.nlm.nih.gov/pubmed/34608617 http://dx.doi.org/10.1007/s41999-021-00565-6 |
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author | Welch, Carly Greig, Carolyn Majid, Zeinab Masud, Tahir Moorey, Hannah Pinkney, Thomas Jackson, Thomas |
author_facet | Welch, Carly Greig, Carolyn Majid, Zeinab Masud, Tahir Moorey, Hannah Pinkney, Thomas Jackson, Thomas |
author_sort | Welch, Carly |
collection | PubMed |
description | PURPOSE: To assess feasibility of conducting acute sarcopenia research in complex populations of hospitalised older adults. METHODS: Patients ≥ 70 years old were recruited to three cohorts: elective colorectal surgery, emergency (abdominal) surgery, medical patients with infections. Participants were recruited to the elective cohort in preoperative assessment clinic, and acutely admitted participants from surgical and medical wards at the Queen Elizabeth Hospital Birmingham. Serial measures of muscle quantity (ultrasound quadriceps, bioelectrical impedance analysis), muscle function (hand grip strength, physical performance), and questionnaires (mini-nutritional assessment, physical function) were performed at baseline, within 7 (± 2) days of admission/surgery, and 13 (± 1) weeks post-admission/surgery. Feasibility outcomes were assessed across timepoints including recruitment and drop-out rates, and procedure completion rates. RESULTS: Eighty-one participants were recruited (mean age 79, 38.3% females). Recruitment rates were higher in elective (75%, 24/32) compared to emergency surgery (37.2%, 16/43), and medical participants (45.1%, 41/91; p = 0.003). Drop-out rates varied from 8.3 to 19.5% at 7 days, and 12.5–43.9% at 13 weeks. Age and gender did not differ between patients assessed for eligibility, approached, or recruited. Completion rates were highest for ultrasound quadriceps (98.8%, 80/81 across all groups at baseline). Gait speed completion rates were lower in medical (70.7%, 29/41) compared to elective participants (100%, 24/24) at baseline. CONCLUSION: Higher participation refusal and drop-out rates should be expected for research involving recruitment of participants from the acute setting. Assessment of muscle quantity/quality through ultrasound is recommended in early-stage trials in the acute setting, where completion rates of physical performance testing are expected to be lower. |
format | Online Article Text |
id | pubmed-8490139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-84901392021-10-05 The feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study Welch, Carly Greig, Carolyn Majid, Zeinab Masud, Tahir Moorey, Hannah Pinkney, Thomas Jackson, Thomas Eur Geriatr Med Research Paper PURPOSE: To assess feasibility of conducting acute sarcopenia research in complex populations of hospitalised older adults. METHODS: Patients ≥ 70 years old were recruited to three cohorts: elective colorectal surgery, emergency (abdominal) surgery, medical patients with infections. Participants were recruited to the elective cohort in preoperative assessment clinic, and acutely admitted participants from surgical and medical wards at the Queen Elizabeth Hospital Birmingham. Serial measures of muscle quantity (ultrasound quadriceps, bioelectrical impedance analysis), muscle function (hand grip strength, physical performance), and questionnaires (mini-nutritional assessment, physical function) were performed at baseline, within 7 (± 2) days of admission/surgery, and 13 (± 1) weeks post-admission/surgery. Feasibility outcomes were assessed across timepoints including recruitment and drop-out rates, and procedure completion rates. RESULTS: Eighty-one participants were recruited (mean age 79, 38.3% females). Recruitment rates were higher in elective (75%, 24/32) compared to emergency surgery (37.2%, 16/43), and medical participants (45.1%, 41/91; p = 0.003). Drop-out rates varied from 8.3 to 19.5% at 7 days, and 12.5–43.9% at 13 weeks. Age and gender did not differ between patients assessed for eligibility, approached, or recruited. Completion rates were highest for ultrasound quadriceps (98.8%, 80/81 across all groups at baseline). Gait speed completion rates were lower in medical (70.7%, 29/41) compared to elective participants (100%, 24/24) at baseline. CONCLUSION: Higher participation refusal and drop-out rates should be expected for research involving recruitment of participants from the acute setting. Assessment of muscle quantity/quality through ultrasound is recommended in early-stage trials in the acute setting, where completion rates of physical performance testing are expected to be lower. Springer International Publishing 2021-10-05 2022 /pmc/articles/PMC8490139/ /pubmed/34608617 http://dx.doi.org/10.1007/s41999-021-00565-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Paper Welch, Carly Greig, Carolyn Majid, Zeinab Masud, Tahir Moorey, Hannah Pinkney, Thomas Jackson, Thomas The feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study |
title | The feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study |
title_full | The feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study |
title_fullStr | The feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study |
title_full_unstemmed | The feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study |
title_short | The feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study |
title_sort | feasibility of conducting acute sarcopenia research in hospitalised older patients: a prospective cohort study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490139/ https://www.ncbi.nlm.nih.gov/pubmed/34608617 http://dx.doi.org/10.1007/s41999-021-00565-6 |
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