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Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals

OBJECTIVES: The present study aimed to evaluate the effects of waste anaesthetic gases on cytokines and oxidative stress of hospital health team members following exposure to waste anaesthetic gases (WAGs). SUBJECTS AND METHODS: In total, 180 participants took part in this study; 60 of these were he...

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Autores principales: AL-Rasheedi, Khaled A., Alqasoumi, Abdulmajeed A., Emara, Ashraf M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490262/
https://www.ncbi.nlm.nih.gov/pubmed/33959815
http://dx.doi.org/10.1007/s00420-021-01705-y
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author AL-Rasheedi, Khaled A.
Alqasoumi, Abdulmajeed A.
Emara, Ashraf M.
author_facet AL-Rasheedi, Khaled A.
Alqasoumi, Abdulmajeed A.
Emara, Ashraf M.
author_sort AL-Rasheedi, Khaled A.
collection PubMed
description OBJECTIVES: The present study aimed to evaluate the effects of waste anaesthetic gases on cytokines and oxidative stress of hospital health team members following exposure to waste anaesthetic gases (WAGs). SUBJECTS AND METHODS: In total, 180 participants took part in this study; 60 of these were healthy male controls and the 120 participants in the intervention group were staff who work in the operating room. This latter group comprises six occupational subgroups (1) surgeons, (2) surgical assistants, (3) anaesthesiologists (4) anaesthesiology assistants, (5) nurses and (6) janitors. The following parameters were assessed: catalase (CAT), glutathione peroxidase (GSHpx) and superoxide dismutase (SOD) activities, plasma fluoride, serum interferon gamma (IFN-γ), serum interleukin 2 (IL2), serum interleukin 4 (IL4) and plasma thiobarbituric acid reactive substances (TBARS). RESULTS: Anaesthesiologists and their assistants exhibited the highest levels of plasma fluoride, serum IFN-γ and IL 2, exceeding the levels in detected in all the other occupational subgroups. Furthermore, the serum levels of IL4 were significantly raised in anaesthesiologists and the difference between this group and other groups was statistically significant. However, compared with the other subgroups, surgeons exhibited elevated plasma TBARS and reduced CAT, GSHpx and SOD; these variances were also statistically significant. CONCLUSION AND RECOMMENDATIONS: The findings of this study indicate that operating room staff exposed to WAGs are vulnerable to experiencing immunotoxicity as the WAGs are considered to initiate oxidative stress and increase the levels of cytokines in serum. Thus, an education programme is warranted to inform staff working in environments where they may be subjected to WAGs on the effects that the gases can have upon their health and how to minimise their exposure to WAGs. An ongoing effort is also needed to ensure anaesthesia safety standards are maintained at all times. The findings of this study may provide a springboard for future research into occupational exposure to WAGs and their wider effect upon health.
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spelling pubmed-84902622021-10-15 Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals AL-Rasheedi, Khaled A. Alqasoumi, Abdulmajeed A. Emara, Ashraf M. Int Arch Occup Environ Health Original Article OBJECTIVES: The present study aimed to evaluate the effects of waste anaesthetic gases on cytokines and oxidative stress of hospital health team members following exposure to waste anaesthetic gases (WAGs). SUBJECTS AND METHODS: In total, 180 participants took part in this study; 60 of these were healthy male controls and the 120 participants in the intervention group were staff who work in the operating room. This latter group comprises six occupational subgroups (1) surgeons, (2) surgical assistants, (3) anaesthesiologists (4) anaesthesiology assistants, (5) nurses and (6) janitors. The following parameters were assessed: catalase (CAT), glutathione peroxidase (GSHpx) and superoxide dismutase (SOD) activities, plasma fluoride, serum interferon gamma (IFN-γ), serum interleukin 2 (IL2), serum interleukin 4 (IL4) and plasma thiobarbituric acid reactive substances (TBARS). RESULTS: Anaesthesiologists and their assistants exhibited the highest levels of plasma fluoride, serum IFN-γ and IL 2, exceeding the levels in detected in all the other occupational subgroups. Furthermore, the serum levels of IL4 were significantly raised in anaesthesiologists and the difference between this group and other groups was statistically significant. However, compared with the other subgroups, surgeons exhibited elevated plasma TBARS and reduced CAT, GSHpx and SOD; these variances were also statistically significant. CONCLUSION AND RECOMMENDATIONS: The findings of this study indicate that operating room staff exposed to WAGs are vulnerable to experiencing immunotoxicity as the WAGs are considered to initiate oxidative stress and increase the levels of cytokines in serum. Thus, an education programme is warranted to inform staff working in environments where they may be subjected to WAGs on the effects that the gases can have upon their health and how to minimise their exposure to WAGs. An ongoing effort is also needed to ensure anaesthesia safety standards are maintained at all times. The findings of this study may provide a springboard for future research into occupational exposure to WAGs and their wider effect upon health. Springer Berlin Heidelberg 2021-05-06 2021 /pmc/articles/PMC8490262/ /pubmed/33959815 http://dx.doi.org/10.1007/s00420-021-01705-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
AL-Rasheedi, Khaled A.
Alqasoumi, Abdulmajeed A.
Emara, Ashraf M.
Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals
title Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals
title_full Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals
title_fullStr Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals
title_full_unstemmed Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals
title_short Effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals
title_sort effect of inhaled anaesthetics gases on cytokines and oxidative stress alterations for the staff health status in hospitals
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490262/
https://www.ncbi.nlm.nih.gov/pubmed/33959815
http://dx.doi.org/10.1007/s00420-021-01705-y
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