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Severe cellular stress activates apoptosis independently of p53 in osteosarcoma

Apoptosis induced by doxorubicin, bortezomib, or paclitaxel, targeting DNA, 26S proteasome, and microtubules respectively, was assessed in two osteosarcoma cells, p53 wild-type U2OS and p53-null MG63 cells. Doxorubicin-induced apoptosis only occurred in U2OS, not in MG63. In contrast, bortezomib and...

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Detalles Bibliográficos
Autores principales:	Ho, Cheng-Jung, Ko, Huey-Jiun, Liao, Tzu-Shao, Zheng, Xiang-Ren, Chou, Po-Hsu, Wang, Li-Ting, Lin, Ru-Wei, Chen, Chung-Hwan, Wang, Chihuei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490387/ https://www.ncbi.nlm.nih.gov/pubmed/34608124 http://dx.doi.org/10.1038/s41420-021-00658-y

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