Upregulated NMDAR-mediated GABAergic transmission underlies autistic-like deficits in Htr3a knockout mice

Mutations in serotonin pathway genes, especially the serotonergic receptor subunit gene HTR3A, are associated with autism. However, the association of HTR3A deficiency with autism and the underlying mechanisms remain unknown. Methods: The Htr3a knockout (KO) mice were generated using transcription a...

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Detalles Bibliográficos
Autores principales: Huang, Lang, Wang, Jing, Liang, Guanmei, Gao, Yue, Jin, Shi-Yang, Hu, Jian, Yang, Xiaoxue, Lao, Jianpei, Chen, Jinfa, Luo, Zhou-Cai, Fan, Cuixia, Xiong, Li, Zhu, Xinhong, Gao, Tian-Ming, Zhong, Mei, Yang, Xinping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490518/
https://www.ncbi.nlm.nih.gov/pubmed/34646371
http://dx.doi.org/10.7150/thno.60531

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