Pyruvate kinase M2 regulates fibrosis development and progression by controlling glycine auxotrophy in myofibroblasts

Rationale: Fibrosis is a pathologic condition of abnormal accumulation of collagen fibrils. Collagen is a major extracellular matrix (ECM) protein synthesized and secreted by myofibroblasts, composing mainly (Gly-X-Y)n triplet repeats with >30% Gly residue. During fibrosis progression, myofibrobl...

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Detalles Bibliográficos
Autores principales: Satyanarayana, Ganesh, Turaga, Ravi Chakra, Sharma, Malvika, Wang, Siming, Mishra, Falguni, Peng, Guangda, Deng, Xiaonan, Yang, Jenny, Liu, Zhi-Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490528/
https://www.ncbi.nlm.nih.gov/pubmed/34646373
http://dx.doi.org/10.7150/thno.60385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490528/
https://www.ncbi.nlm.nih.gov/pubmed/34646373
http://dx.doi.org/10.7150/thno.60385

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