Cargando…
Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study
Lymphocyte-to-monocyte ratio (LMR) has been reported as a biomarker for predicting the prognosis of colorectal cancer. However, the clinical usefulness of LMR requires detailed research, which can contribute to better therapeutic strategies. A cohort of 554 patients with resectable advanced colon ca...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer India
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490554/ https://www.ncbi.nlm.nih.gov/pubmed/34658577 http://dx.doi.org/10.1007/s13193-021-01356-y |
_version_ | 1784578546049482752 |
---|---|
author | Kasahara, Kenta Ishizaki, Tetsuo Enomoto, Masanobu Mazaki, Junichi Okazaki, Naoto Tago, Tomoya Udo, Ryutaro Nagakawa, Yuichi Katsumata, Kenji Tsuchida, Akihiko |
author_facet | Kasahara, Kenta Ishizaki, Tetsuo Enomoto, Masanobu Mazaki, Junichi Okazaki, Naoto Tago, Tomoya Udo, Ryutaro Nagakawa, Yuichi Katsumata, Kenji Tsuchida, Akihiko |
author_sort | Kasahara, Kenta |
collection | PubMed |
description | Lymphocyte-to-monocyte ratio (LMR) has been reported as a biomarker for predicting the prognosis of colorectal cancer. However, the clinical usefulness of LMR requires detailed research, which can contribute to better therapeutic strategies. A cohort of 554 patients with resectable advanced colon cancer in our institution was analyzed retrospectively. An analysis of stages II and III resectable advanced colon cancer was performed. LMR was useful for predicting overall survival (OS) and relapse-free survival (RFS). The ROC curve revealed an LMR value of 2.77 as a cutoff for OS. A high LMR was an independent prognostic factor and was associated with a high hazard ratio (HR) in all cases for OS (HR = 0.530, 95% confidence interval (CI) = 0.334–0.842, p = 0.007). A high LMR was not an independent prognostic factor in stage II cases but was a predictor with the strongest association with prognosis in patients with stage III cases for OS (HR = 0.383, 95% CI = 0.160–0.915, p = 0.031). LMR is a strong predictor of prognosis in patients with stage III colon cancer and may be useful in postoperative treatment options. |
format | Online Article Text |
id | pubmed-8490554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer India |
record_format | MEDLINE/PubMed |
spelling | pubmed-84905542021-10-15 Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study Kasahara, Kenta Ishizaki, Tetsuo Enomoto, Masanobu Mazaki, Junichi Okazaki, Naoto Tago, Tomoya Udo, Ryutaro Nagakawa, Yuichi Katsumata, Kenji Tsuchida, Akihiko Indian J Surg Oncol Original Article Lymphocyte-to-monocyte ratio (LMR) has been reported as a biomarker for predicting the prognosis of colorectal cancer. However, the clinical usefulness of LMR requires detailed research, which can contribute to better therapeutic strategies. A cohort of 554 patients with resectable advanced colon cancer in our institution was analyzed retrospectively. An analysis of stages II and III resectable advanced colon cancer was performed. LMR was useful for predicting overall survival (OS) and relapse-free survival (RFS). The ROC curve revealed an LMR value of 2.77 as a cutoff for OS. A high LMR was an independent prognostic factor and was associated with a high hazard ratio (HR) in all cases for OS (HR = 0.530, 95% confidence interval (CI) = 0.334–0.842, p = 0.007). A high LMR was not an independent prognostic factor in stage II cases but was a predictor with the strongest association with prognosis in patients with stage III cases for OS (HR = 0.383, 95% CI = 0.160–0.915, p = 0.031). LMR is a strong predictor of prognosis in patients with stage III colon cancer and may be useful in postoperative treatment options. Springer India 2021-07-08 2021-09 /pmc/articles/PMC8490554/ /pubmed/34658577 http://dx.doi.org/10.1007/s13193-021-01356-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Kasahara, Kenta Ishizaki, Tetsuo Enomoto, Masanobu Mazaki, Junichi Okazaki, Naoto Tago, Tomoya Udo, Ryutaro Nagakawa, Yuichi Katsumata, Kenji Tsuchida, Akihiko Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study |
title | Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study |
title_full | Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study |
title_fullStr | Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study |
title_full_unstemmed | Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study |
title_short | Preoperative Lymphocyte-to-Monocyte Ratio in the Prognostication of Advanced Resectable Colon Cancer: a Retrospective Observational Study |
title_sort | preoperative lymphocyte-to-monocyte ratio in the prognostication of advanced resectable colon cancer: a retrospective observational study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490554/ https://www.ncbi.nlm.nih.gov/pubmed/34658577 http://dx.doi.org/10.1007/s13193-021-01356-y |
work_keys_str_mv | AT kasaharakenta preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy AT ishizakitetsuo preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy AT enomotomasanobu preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy AT mazakijunichi preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy AT okazakinaoto preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy AT tagotomoya preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy AT udoryutaro preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy AT nagakawayuichi preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy AT katsumatakenji preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy AT tsuchidaakihiko preoperativelymphocytetomonocyteratiointheprognosticationofadvancedresectablecoloncanceraretrospectiveobservationalstudy |