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Macroautophagy and normal aging of the nervous system: Lessons from animal models

Aging represents a cumulative form of cellular stress, which is thought to challenge many aspects of proteostasis. The non-dividing, long-lived neurons are particularly vulnerable to stress, and, not surprisingly, even normal aging is highly associated with a decline in brain function in humans, as...

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Autores principales: Kallergi, Emmanouela, Nikoletopoulou, Vassiliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490955/
https://www.ncbi.nlm.nih.gov/pubmed/34708187
http://dx.doi.org/10.15698/cst2021.10.257
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author Kallergi, Emmanouela
Nikoletopoulou, Vassiliki
author_facet Kallergi, Emmanouela
Nikoletopoulou, Vassiliki
author_sort Kallergi, Emmanouela
collection PubMed
description Aging represents a cumulative form of cellular stress, which is thought to challenge many aspects of proteostasis. The non-dividing, long-lived neurons are particularly vulnerable to stress, and, not surprisingly, even normal aging is highly associated with a decline in brain function in humans, as well as in other animals. Macroautophagy is a fundamental arm of the proteostasis network, safeguarding proper protein turnover during different cellular states and against diverse cellular stressors. An intricate interplay between macroautophagy and aging is beginning to unravel, with the emergence of new tools, including those for monitoring autophagy in cultured neurons and in the nervous system of different organisms in vivo. Here, we review recent findings on the impact of aging on neuronal integrity and on neuronal macroautophagy, as they emerge from studies in invertebrate and mammalian models.
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spelling pubmed-84909552021-10-26 Macroautophagy and normal aging of the nervous system: Lessons from animal models Kallergi, Emmanouela Nikoletopoulou, Vassiliki Cell Stress Review Aging represents a cumulative form of cellular stress, which is thought to challenge many aspects of proteostasis. The non-dividing, long-lived neurons are particularly vulnerable to stress, and, not surprisingly, even normal aging is highly associated with a decline in brain function in humans, as well as in other animals. Macroautophagy is a fundamental arm of the proteostasis network, safeguarding proper protein turnover during different cellular states and against diverse cellular stressors. An intricate interplay between macroautophagy and aging is beginning to unravel, with the emergence of new tools, including those for monitoring autophagy in cultured neurons and in the nervous system of different organisms in vivo. Here, we review recent findings on the impact of aging on neuronal integrity and on neuronal macroautophagy, as they emerge from studies in invertebrate and mammalian models. Shared Science Publishers OG 2021-10-06 /pmc/articles/PMC8490955/ /pubmed/34708187 http://dx.doi.org/10.15698/cst2021.10.257 Text en Copyright: © 2021 Kallergi and Nikoletopoulou https://creativecommons.org/licenses/by/4.0/This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Review
Kallergi, Emmanouela
Nikoletopoulou, Vassiliki
Macroautophagy and normal aging of the nervous system: Lessons from animal models
title Macroautophagy and normal aging of the nervous system: Lessons from animal models
title_full Macroautophagy and normal aging of the nervous system: Lessons from animal models
title_fullStr Macroautophagy and normal aging of the nervous system: Lessons from animal models
title_full_unstemmed Macroautophagy and normal aging of the nervous system: Lessons from animal models
title_short Macroautophagy and normal aging of the nervous system: Lessons from animal models
title_sort macroautophagy and normal aging of the nervous system: lessons from animal models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490955/
https://www.ncbi.nlm.nih.gov/pubmed/34708187
http://dx.doi.org/10.15698/cst2021.10.257
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