Cargando…

BRD9 is a druggable component of interferon‐stimulated gene expression and antiviral activity

Interferon (IFN) induction of IFN‐stimulated genes (ISGs) creates a formidable protective antiviral state. However, loss of appropriate control mechanisms can result in constitutive pathogenic ISG upregulation. Here, we used genome‐scale loss‐of‐function screening to establish genes critical for IFN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Börold, Jacob, Eletto, Davide, Busnadiego, Idoia, Mair, Nina K, Moritz, Eva, Schiefer, Samira, Schmidt, Nora, Petric, Philipp P, Wong, W Wei‐Lynn, Schwemmle, Martin, Hale, Benjamin G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490982/ https://www.ncbi.nlm.nih.gov/pubmed/34397140 http://dx.doi.org/10.15252/embr.202152823

Ejemplares similares

Ultra-Rare BRD9 Loss-of-Function Variants Limit the Antiviral Action of Interferon
por: Mair, Nina K., et al.
Publicado: (2022)

Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2
por: Busnadiego, Idoia, et al.
Publicado: (2020)

Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
por: Fernbach, Sonja, et al.
Publicado: (2022)

FACT subunit SUPT16H associates with BRD4 and contributes to silencing of antiviral interferon signaling
por: Zhou, Dawei, et al.
Publicado: (2021)

Identification of New Druggable Antiviral Targets by Chemical Genetics
por: Kao, Richard Y., et al.
Publicado: (2011)

Druggable targets from coronaviruses for designing new antiviral drugs
por: Silva, Leandro Rocha, et al.
Publicado: (2020)

Histone H2A.Z Suppression of Interferon-Stimulated Transcription and Antiviral Immunity Is Modulated by GCN5 and BRD2
por: Au-Yeung, Nancy, et al.
Publicado: (2018)

BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4
por: Ahmed, Nasiha S., et al.
Publicado: (2021)

Critically ill COVID-19 patients with neutralizing autoantibodies against type I interferons have increased risk of herpesvirus disease
por: Busnadiego, Idoia, et al.
Publicado: (2022)

The Envelope Gene of Transmitted HIV-1 Resists a Late Interferon Gamma-Induced Block
por: Rihn, Suzannah J., et al.
Publicado: (2017)

Bromodomain-containing subunits BRD1, BRD2, and BRD13 are required for proper functioning of SWI/SNF complexes in Arabidopsis
por: Jarończyk, Kamila, et al.
Publicado: (2021)

Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma
por: Seier, Johanna A, et al.
Publicado: (2021)

Antiviral activities of interferons
por: Stewart, William E., et al.
Publicado: (1979)

Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
por: Martín-Acebes, Miguel A., et al.
Publicado: (2019)

FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling
por: Zhou, Dawei, et al.
Publicado: (2022)

KRAS: Druggable at Last
por: Herzberg, Benjamin O, et al.
Publicado: (2023)

Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses
por: Artese, Anna, et al.
Publicado: (2020)

Interferon-inducible antiviral effectors
por: Sadler, Anthony J., et al.
Publicado: (2008)

Antiviral defense: interferons and beyond
por: Stetson, Daniel B., et al.
Publicado: (2006)

Avian Interferons and Their Antiviral Effectors
por: Santhakumar, Diwakar, et al.
Publicado: (2017)

Retraction Note: Interferon-mediated antiviral activities of Angelica tenuissima Nakai and its active components
por: Weeratunga, Prasanna, et al.
Publicado: (2018)

RETRACTED ARTICLE: Interferon-mediated antiviral activities of Angelica tenuissima Nakai and its active components
por: Weeratunga, Prasanna, et al.
Publicado: (2016)

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes
por: Hügle, Martin, et al.
Publicado: (2016)

Anti-influenza A virus restriction factors that shape the human species barrier and virus evolution
por: Petric, Philipp Peter, et al.
Publicado: (2023)

The Infectious Bursal Disease Virus RNA-Binding VP3 Polypeptide Inhibits PKR-Mediated Apoptosis
por: Busnadiego, Idoia, et al.
Publicado: (2012)

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell
por: Deeney, Jude T., et al.
Publicado: (2016)

The Druggable Pocketome of Corynebacterium diphtheriae: A New Approach for in silico Putative Druggable Targets
por: Hassan, Syed S., et al.
Publicado: (2018)

DGIdb - Mining the druggable genome
por: Griffith, Malachi, et al.
Publicado: (2013)

Druggable Drivers of Lung Cancer
por: Fawdar, Shameem, et al.
Publicado: (2013)

Development of the Antiviral State in Response to Interferon
por: Sonnabend, Joseph A., et al.
Publicado: (1970)

Direct Antiviral Mechanisms of Interferon-Gamma
por: Kang, Soowon, et al.
Publicado: (2018)

Interferons: Signaling, antiviral and viral evasion
por: Bonjardim, Cláudio A., et al.
Publicado: (2009)

The regulation of antiviral activity of interferon epsilon
por: Zhao, Fu-Rong, et al.
Publicado: (2022)

Viral recognition and the antiviral interferon response
por: Dalskov, Louise, et al.
Publicado: (2023)

A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages
por: Bamford, Connor G. G., et al.
Publicado: (2018)

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis
por: Roberts, Thomas C., et al.
Publicado: (2017)

An integrated structural proteomics approach along the druggable genome of Corynebacterium pseudotuberculosis species for putative druggable targets
por: Radusky, Leandro G, et al.
Publicado: (2015)

Comparative Evaluation of Antimicrobial, Antiamoebic, and Antiviral Efficacy of Ophthalmic Formulations
por: Caruso, Ciro, et al.
Publicado: (2022)

The Plasmodium Lactate/H(+) Transporter PfFNT Is Essential and Druggable In Vivo
por: Davies, Heledd, et al.
Publicado: (2023)

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response
por: Lucas-Hourani, Marianne, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fh9n029qbsebuunjf3eg20ki2e