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Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance

AIM: To investigate whether vertebrobasilar geometry contributes to the presence, severity, and laterality of white matter hyperintensities (WMH). METHODS: We retrospectively reviewed 290 cerebral scans of patients who underwent time-of-flight and fluid-attenuated inversion recovery (FLAIR) magnetic...

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Autores principales: Szalontai, Laszlo, Jokkel, Zsofia, Horvath, Tamas, Forgo, Bianka, Kalina, Ildiko, Maurovich-Horvat, Pal, Auyang, Philip L., Zubair, M. Mujeeb, Garami, Zsolt, Tarnoki, David Laszlo, Tarnoki, Adam Domonkos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491045/
https://www.ncbi.nlm.nih.gov/pubmed/34472739
http://dx.doi.org/10.3325/cmj.2021.62.360
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author Szalontai, Laszlo
Jokkel, Zsofia
Horvath, Tamas
Forgo, Bianka
Kalina, Ildiko
Maurovich-Horvat, Pal
Auyang, Philip L.
Zubair, M. Mujeeb
Garami, Zsolt
Tarnoki, David Laszlo
Tarnoki, Adam Domonkos
author_facet Szalontai, Laszlo
Jokkel, Zsofia
Horvath, Tamas
Forgo, Bianka
Kalina, Ildiko
Maurovich-Horvat, Pal
Auyang, Philip L.
Zubair, M. Mujeeb
Garami, Zsolt
Tarnoki, David Laszlo
Tarnoki, Adam Domonkos
author_sort Szalontai, Laszlo
collection PubMed
description AIM: To investigate whether vertebrobasilar geometry contributes to the presence, severity, and laterality of white matter hyperintensities (WMH). METHODS: We retrospectively reviewed 290 cerebral scans of patients who underwent time-of-flight and fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) between 2017 and 2018. WMH were counted, localized, and grouped according to laterality on the FLAIR sequence. A 3D mesh of the posterior circulation was reconstructed (with ITK SNAP software) and the morphology of the vertebrobasilar system analyzed with an in-house software written in Python. RESULTS: Patients were assigned into a group with WMH (n = 204) and a group without WMH (n = 86). The severity of WMH burden was mainly affected by age and hypertension, while the localization of the WMH (or laterality) was mainly affected by the vertebrobasilar system morphology. Basilar artery morphology only affected the parieto-occipital region significantly if both posterior communicating arteries were hypoplastic or absent. The dominant vertebral artery and basilar artery curve had an opposite directional relationship. CONCLUSIONS: An unequal vertebral artery flow is an important hemodynamic contributor to basilar bending. Increased basilar artery curvature and increased infratentorial WMH burden may signal inadequate blood flow and predict cerebrovascular events.
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spelling pubmed-84910452021-10-13 Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance Szalontai, Laszlo Jokkel, Zsofia Horvath, Tamas Forgo, Bianka Kalina, Ildiko Maurovich-Horvat, Pal Auyang, Philip L. Zubair, M. Mujeeb Garami, Zsolt Tarnoki, David Laszlo Tarnoki, Adam Domonkos Croat Med J Research Article AIM: To investigate whether vertebrobasilar geometry contributes to the presence, severity, and laterality of white matter hyperintensities (WMH). METHODS: We retrospectively reviewed 290 cerebral scans of patients who underwent time-of-flight and fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) between 2017 and 2018. WMH were counted, localized, and grouped according to laterality on the FLAIR sequence. A 3D mesh of the posterior circulation was reconstructed (with ITK SNAP software) and the morphology of the vertebrobasilar system analyzed with an in-house software written in Python. RESULTS: Patients were assigned into a group with WMH (n = 204) and a group without WMH (n = 86). The severity of WMH burden was mainly affected by age and hypertension, while the localization of the WMH (or laterality) was mainly affected by the vertebrobasilar system morphology. Basilar artery morphology only affected the parieto-occipital region significantly if both posterior communicating arteries were hypoplastic or absent. The dominant vertebral artery and basilar artery curve had an opposite directional relationship. CONCLUSIONS: An unequal vertebral artery flow is an important hemodynamic contributor to basilar bending. Increased basilar artery curvature and increased infratentorial WMH burden may signal inadequate blood flow and predict cerebrovascular events. Croatian Medical Schools 2021-08 /pmc/articles/PMC8491045/ /pubmed/34472739 http://dx.doi.org/10.3325/cmj.2021.62.360 Text en Copyright © 2021 by the Croatian Medical Journal. All rights reserved. https://creativecommons.org/licenses/by/2.5/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Szalontai, Laszlo
Jokkel, Zsofia
Horvath, Tamas
Forgo, Bianka
Kalina, Ildiko
Maurovich-Horvat, Pal
Auyang, Philip L.
Zubair, M. Mujeeb
Garami, Zsolt
Tarnoki, David Laszlo
Tarnoki, Adam Domonkos
Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance
title Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance
title_full Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance
title_fullStr Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance
title_full_unstemmed Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance
title_short Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance
title_sort laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491045/
https://www.ncbi.nlm.nih.gov/pubmed/34472739
http://dx.doi.org/10.3325/cmj.2021.62.360
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