Synthesis of the C1–C27 Fragment of Stambomycin D Validates Modular Polyketide Synthase-Based Stereochemical Assignments

[Image: see text] The stambomycins are a family of bioactive macrolides isolated from Streptomyces ambofaciens. Aside from two stereocenters installed through cytochrome P450 oxidations, their stereochemistry has been predicted by sequence analysis of the polyketide synthase. We report a synthesis o...

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Detalles Bibliográficos
Autores principales: Lim, Jieyan, Chintalapudi, Venkaiah, Gudmundsson, Haraldur G., Tran, Minh, Bernasconi, Alice, Blanco, Araceli, Song, Lijiang, Challis, Gregory L., Anderson, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491158/
https://www.ncbi.nlm.nih.gov/pubmed/34494848
http://dx.doi.org/10.1021/acs.orglett.1c02650

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