Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy

A schematic illustration is given regarding serine restriction on tumor growth. Once the cellular abundance of serine decreased or alanine accumulated, the serine palmitoyltransferase (SPT) alternatively conjugates alanine and palmitoyl‐CoA to form 3‐keto‐intermediates, which is rapidly converted to...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiang, Yuancai, Zhao, Kun, Tang, Yi‐Quan, Dai, Rongyang, Miao, Hongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491209/
https://www.ncbi.nlm.nih.gov/pubmed/34766138
http://dx.doi.org/10.1002/mco2.44
Descripción
Sumario:A schematic illustration is given regarding serine restriction on tumor growth. Once the cellular abundance of serine decreased or alanine accumulated, the serine palmitoyltransferase (SPT) alternatively conjugates alanine and palmitoyl‐CoA to form 3‐keto‐intermediates, which is rapidly converted to 1‐deoxysphinganine and further metabolized to 1‐deoxydihydroceramide (1‐DeoxyDHCER) and 1‐deoxyceramide (1‐DeoxyDHCER), so that to exert cytotoxicity for tumor suppression. [Image: see text]

Ejemplares similares