Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy

A schematic illustration is given regarding serine restriction on tumor growth. Once the cellular abundance of serine decreased or alanine accumulated, the serine palmitoyltransferase (SPT) alternatively conjugates alanine and palmitoyl‐CoA to form 3‐keto‐intermediates, which is rapidly converted to...

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Autores principales: Xiang, Yuancai, Zhao, Kun, Tang, Yi‐Quan, Dai, Rongyang, Miao, Hongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Highlights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491209/
https://www.ncbi.nlm.nih.gov/pubmed/34766138
http://dx.doi.org/10.1002/mco2.44
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author Xiang, Yuancai
Zhao, Kun
Tang, Yi‐Quan
Dai, Rongyang
Miao, Hongming
author_facet Xiang, Yuancai
Zhao, Kun
Tang, Yi‐Quan
Dai, Rongyang
Miao, Hongming
author_sort Xiang, Yuancai
collection PubMed
description A schematic illustration is given regarding serine restriction on tumor growth. Once the cellular abundance of serine decreased or alanine accumulated, the serine palmitoyltransferase (SPT) alternatively conjugates alanine and palmitoyl‐CoA to form 3‐keto‐intermediates, which is rapidly converted to 1‐deoxysphinganine and further metabolized to 1‐deoxydihydroceramide (1‐DeoxyDHCER) and 1‐deoxyceramide (1‐DeoxyDHCER), so that to exert cytotoxicity for tumor suppression. [Image: see text]
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spelling pubmed-84912092021-11-10 Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy Xiang, Yuancai Zhao, Kun Tang, Yi‐Quan Dai, Rongyang Miao, Hongming MedComm (2020) Highlights A schematic illustration is given regarding serine restriction on tumor growth. Once the cellular abundance of serine decreased or alanine accumulated, the serine palmitoyltransferase (SPT) alternatively conjugates alanine and palmitoyl‐CoA to form 3‐keto‐intermediates, which is rapidly converted to 1‐deoxysphinganine and further metabolized to 1‐deoxydihydroceramide (1‐DeoxyDHCER) and 1‐deoxyceramide (1‐DeoxyDHCER), so that to exert cytotoxicity for tumor suppression. [Image: see text] John Wiley and Sons Inc. 2020-12-31 /pmc/articles/PMC8491209/ /pubmed/34766138 http://dx.doi.org/10.1002/mco2.44 Text en © 2020 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Highlights
Xiang, Yuancai
Zhao, Kun
Tang, Yi‐Quan
Dai, Rongyang
Miao, Hongming
Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
title Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
title_full Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
title_fullStr Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
title_full_unstemmed Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
title_short Modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
title_sort modulating serine palmitoyltransferase‐deoxysphingolipid axis in cancer therapy
topic Highlights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491209/
https://www.ncbi.nlm.nih.gov/pubmed/34766138
http://dx.doi.org/10.1002/mco2.44
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