The biological role of metabolic reprogramming in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease and highly resistant to all forms of therapy. PDAC cells reprogram their metabolism extensively to promote their survival and growth. Reflecting the vital role of altered metabolism, experimental and clinical trials targeting the rewired me...

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Detalles Bibliográficos
Autores principales: Suzuki, Tatsunori, Otsuka, Motoyuki, Seimiya, Takahiro, Iwata, Takuma, Kishikawa, Takahiro, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491225/
https://www.ncbi.nlm.nih.gov/pubmed/34766124
http://dx.doi.org/10.1002/mco2.37
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author Suzuki, Tatsunori
Otsuka, Motoyuki
Seimiya, Takahiro
Iwata, Takuma
Kishikawa, Takahiro
Koike, Kazuhiko
author_facet Suzuki, Tatsunori
Otsuka, Motoyuki
Seimiya, Takahiro
Iwata, Takuma
Kishikawa, Takahiro
Koike, Kazuhiko
author_sort Suzuki, Tatsunori
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease and highly resistant to all forms of therapy. PDAC cells reprogram their metabolism extensively to promote their survival and growth. Reflecting the vital role of altered metabolism, experimental and clinical trials targeting the rewired metabolism are currently underway. In this review, we summarize the vital role of metabolic reprogramming in the development of PDAC and the future of novel therapeutic applications.
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spelling pubmed-84912252021-11-10 The biological role of metabolic reprogramming in pancreatic cancer Suzuki, Tatsunori Otsuka, Motoyuki Seimiya, Takahiro Iwata, Takuma Kishikawa, Takahiro Koike, Kazuhiko MedComm (2020) Reviews Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease and highly resistant to all forms of therapy. PDAC cells reprogram their metabolism extensively to promote their survival and growth. Reflecting the vital role of altered metabolism, experimental and clinical trials targeting the rewired metabolism are currently underway. In this review, we summarize the vital role of metabolic reprogramming in the development of PDAC and the future of novel therapeutic applications. John Wiley and Sons Inc. 2020-11-05 /pmc/articles/PMC8491225/ /pubmed/34766124 http://dx.doi.org/10.1002/mco2.37 Text en © 2020 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Suzuki, Tatsunori
Otsuka, Motoyuki
Seimiya, Takahiro
Iwata, Takuma
Kishikawa, Takahiro
Koike, Kazuhiko
The biological role of metabolic reprogramming in pancreatic cancer
title The biological role of metabolic reprogramming in pancreatic cancer
title_full The biological role of metabolic reprogramming in pancreatic cancer
title_fullStr The biological role of metabolic reprogramming in pancreatic cancer
title_full_unstemmed The biological role of metabolic reprogramming in pancreatic cancer
title_short The biological role of metabolic reprogramming in pancreatic cancer
title_sort biological role of metabolic reprogramming in pancreatic cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491225/
https://www.ncbi.nlm.nih.gov/pubmed/34766124
http://dx.doi.org/10.1002/mco2.37
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