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Combined inhibition of CXCL12 and PD-1 in MSS colorectal and pancreatic cancer: modulation of the microenvironment and clinical effects

BACKGROUND: Immunotherapy in microsatellite stable colorectal or pancreatic cancer has not shown promising results. It has been hypothesized that targeting immunosuppressive molecules like SDF1-alpha/CXCL12 could contribute to immunotherapy and animal models showed promising results on T cell activa...

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Detalles Bibliográficos
Autores principales:	Suarez-Carmona, Meggy, Williams, Anja, Schreiber, Jutta, Hohmann, Nicolas, Pruefer, Ulrike, Krauss, Jürgen, Jäger, Dirk, Frömming, Anna, Beyer, Diana, Eulberg, Dirk, Jungelius, Jarf Ulf, Baumann, Matthias, Mangasarian, Aram, Halama, Niels
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491418/ https://www.ncbi.nlm.nih.gov/pubmed/34607895 http://dx.doi.org/10.1136/jitc-2021-002505

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