Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors

INTRODUCTION: Mismatch repair (MMR)-deficient and DNA polymerase epsilon (POLE)-mutated tumors exhibit a high tumor mutation burden (TMB) and have been proven to be associated with good responses to immune checkpoint inhibitor treatments. However, the relationship between mutational characteristics...

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Detalles Bibliográficos
Autores principales: Hwang, Hee Sang, Kim, Deokhoon, Choi, Jene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491424/
https://www.ncbi.nlm.nih.gov/pubmed/34607897
http://dx.doi.org/10.1136/jitc-2021-002797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491424/
https://www.ncbi.nlm.nih.gov/pubmed/34607897
http://dx.doi.org/10.1136/jitc-2021-002797

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