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Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors

INTRODUCTION: Mismatch repair (MMR)-deficient and DNA polymerase epsilon (POLE)-mutated tumors exhibit a high tumor mutation burden (TMB) and have been proven to be associated with good responses to immune checkpoint inhibitor treatments. However, the relationship between mutational characteristics...

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Detalles Bibliográficos
Autores principales:	Hwang, Hee Sang, Kim, Deokhoon, Choi, Jene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491424/ https://www.ncbi.nlm.nih.gov/pubmed/34607897 http://dx.doi.org/10.1136/jitc-2021-002797

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