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Polymorphic variants in genes related to stress coping are associated with the awake bruxism
BACKGROUND: Chronic stress is one of the leading predisposing factors in bruxism aetiology, but the influence of genetic factors is also suggested. We aimed to study whether sequence variants in genes involved in stress regulation pathways: NTRK2 and BDNF, may be associated with awake bruxism suscep...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491599/ https://www.ncbi.nlm.nih.gov/pubmed/34610834 http://dx.doi.org/10.1186/s12903-021-01844-1 |
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author | Maciejewska-Szaniec, Zofia Kaczmarek-Ryś, Marta Hryhorowicz, Szymon Przystańska, Agnieszka Gredes, Tomasz Maciejewska, Barbara Hoppe-Gołębiewska, Justyna Słomski, Ryszard Pławski, Andrzej Czajka-Jakubowska, Agata |
author_facet | Maciejewska-Szaniec, Zofia Kaczmarek-Ryś, Marta Hryhorowicz, Szymon Przystańska, Agnieszka Gredes, Tomasz Maciejewska, Barbara Hoppe-Gołębiewska, Justyna Słomski, Ryszard Pławski, Andrzej Czajka-Jakubowska, Agata |
author_sort | Maciejewska-Szaniec, Zofia |
collection | PubMed |
description | BACKGROUND: Chronic stress is one of the leading predisposing factors in bruxism aetiology, but the influence of genetic factors is also suggested. We aimed to study whether sequence variants in genes involved in stress regulation pathways: NTRK2 and BDNF, may be associated with awake bruxism susceptibility, clinical presentation, and patients’ perceived stress level. METHODS: The study group included 104 patients with probable awake bruxism and 191 population controls. Patients underwent dental examination concerning the symptoms of bruxism and psychological testing. Genotyping was performed using HRMA and sequencing. Statistical analyses were conducted, and P values below 0.05 were considered statistically significant. RESULTS: We observed a positive correlation of measured stress level and pathological teeth attrition in the anterior segment (r = 0.45, P < 0.001), enamel attritions (r = 0.44, P < 0.001), tongue impressions (r = 0.50, P < 0.001) and posterior teeth attrition (r = 0.27, P = 0.005). Moreover, the c.196A variant (p.66Met) of the BDNF gene and c.1397-31392G allele of the NTRK2 gene were present with elevated frequency, comparing to controls. CONCLUSIONS: This study hence the thesis that perceived stress level is a substantial contributing factor to awake bruxism occurrence and its clinical manifestations. Moreover, sequence variants in genes related to stress coping may be correlated with awake bruxism’s susceptibility via elevated perceived stress level. |
format | Online Article Text |
id | pubmed-8491599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-84915992021-10-06 Polymorphic variants in genes related to stress coping are associated with the awake bruxism Maciejewska-Szaniec, Zofia Kaczmarek-Ryś, Marta Hryhorowicz, Szymon Przystańska, Agnieszka Gredes, Tomasz Maciejewska, Barbara Hoppe-Gołębiewska, Justyna Słomski, Ryszard Pławski, Andrzej Czajka-Jakubowska, Agata BMC Oral Health Research BACKGROUND: Chronic stress is one of the leading predisposing factors in bruxism aetiology, but the influence of genetic factors is also suggested. We aimed to study whether sequence variants in genes involved in stress regulation pathways: NTRK2 and BDNF, may be associated with awake bruxism susceptibility, clinical presentation, and patients’ perceived stress level. METHODS: The study group included 104 patients with probable awake bruxism and 191 population controls. Patients underwent dental examination concerning the symptoms of bruxism and psychological testing. Genotyping was performed using HRMA and sequencing. Statistical analyses were conducted, and P values below 0.05 were considered statistically significant. RESULTS: We observed a positive correlation of measured stress level and pathological teeth attrition in the anterior segment (r = 0.45, P < 0.001), enamel attritions (r = 0.44, P < 0.001), tongue impressions (r = 0.50, P < 0.001) and posterior teeth attrition (r = 0.27, P = 0.005). Moreover, the c.196A variant (p.66Met) of the BDNF gene and c.1397-31392G allele of the NTRK2 gene were present with elevated frequency, comparing to controls. CONCLUSIONS: This study hence the thesis that perceived stress level is a substantial contributing factor to awake bruxism occurrence and its clinical manifestations. Moreover, sequence variants in genes related to stress coping may be correlated with awake bruxism’s susceptibility via elevated perceived stress level. BioMed Central 2021-10-05 /pmc/articles/PMC8491599/ /pubmed/34610834 http://dx.doi.org/10.1186/s12903-021-01844-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Maciejewska-Szaniec, Zofia Kaczmarek-Ryś, Marta Hryhorowicz, Szymon Przystańska, Agnieszka Gredes, Tomasz Maciejewska, Barbara Hoppe-Gołębiewska, Justyna Słomski, Ryszard Pławski, Andrzej Czajka-Jakubowska, Agata Polymorphic variants in genes related to stress coping are associated with the awake bruxism |
title | Polymorphic variants in genes related to stress coping are associated with the awake bruxism |
title_full | Polymorphic variants in genes related to stress coping are associated with the awake bruxism |
title_fullStr | Polymorphic variants in genes related to stress coping are associated with the awake bruxism |
title_full_unstemmed | Polymorphic variants in genes related to stress coping are associated with the awake bruxism |
title_short | Polymorphic variants in genes related to stress coping are associated with the awake bruxism |
title_sort | polymorphic variants in genes related to stress coping are associated with the awake bruxism |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491599/ https://www.ncbi.nlm.nih.gov/pubmed/34610834 http://dx.doi.org/10.1186/s12903-021-01844-1 |
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