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Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons

Many investigators who make extracellular recordings from populations of cortical neurons are now using spike shape parameters, and particularly spike duration, as a means of classifying different neuronal sub-types. Because of the nature of the experimental approach, particularly that involving non...

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Detalles Bibliográficos
Autores principales: Lemon, Roger N, Baker, Stuart N, Kraskov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491674/
https://www.ncbi.nlm.nih.gov/pubmed/34117760
http://dx.doi.org/10.1093/cercor/bhab147
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author Lemon, Roger N
Baker, Stuart N
Kraskov, Alexander
author_facet Lemon, Roger N
Baker, Stuart N
Kraskov, Alexander
author_sort Lemon, Roger N
collection PubMed
description Many investigators who make extracellular recordings from populations of cortical neurons are now using spike shape parameters, and particularly spike duration, as a means of classifying different neuronal sub-types. Because of the nature of the experimental approach, particularly that involving nonhuman primates, it is very difficult to validate directly which spike characteristics belong to particular types of pyramidal neurons and interneurons, as defined by modern histological approaches. This commentary looks at the way antidromic identification of pyramidal cells projecting to different targets, and in particular, pyramidal tract neurons (PTN), can inform the utility of spike width classification. Spike duration may provide clues to a diversity of function across the pyramidal cell population, and also highlights important differences that exist across species. Our studies suggest that further electrophysiological and optogenetic approaches are needed to validate spike duration as a means of cell classification and to relate this to well-established histological differences in neocortical cell types.
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spelling pubmed-84916742021-10-06 Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons Lemon, Roger N Baker, Stuart N Kraskov, Alexander Cereb Cortex Feature Article Many investigators who make extracellular recordings from populations of cortical neurons are now using spike shape parameters, and particularly spike duration, as a means of classifying different neuronal sub-types. Because of the nature of the experimental approach, particularly that involving nonhuman primates, it is very difficult to validate directly which spike characteristics belong to particular types of pyramidal neurons and interneurons, as defined by modern histological approaches. This commentary looks at the way antidromic identification of pyramidal cells projecting to different targets, and in particular, pyramidal tract neurons (PTN), can inform the utility of spike width classification. Spike duration may provide clues to a diversity of function across the pyramidal cell population, and also highlights important differences that exist across species. Our studies suggest that further electrophysiological and optogenetic approaches are needed to validate spike duration as a means of cell classification and to relate this to well-established histological differences in neocortical cell types. Oxford University Press 2021-06-12 /pmc/articles/PMC8491674/ /pubmed/34117760 http://dx.doi.org/10.1093/cercor/bhab147 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Feature Article
Lemon, Roger N
Baker, Stuart N
Kraskov, Alexander
Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons
title Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons
title_full Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons
title_fullStr Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons
title_full_unstemmed Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons
title_short Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons
title_sort classification of cortical neurons by spike shape and the identification of pyramidal neurons
topic Feature Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491674/
https://www.ncbi.nlm.nih.gov/pubmed/34117760
http://dx.doi.org/10.1093/cercor/bhab147
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