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Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences
Social communication differences are seen in autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive–compulsive disorder (OCD), but the brain mechanisms contributing to these differences remain largely unknown. To address this gap, we used a data-driven and dia...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491692/ https://www.ncbi.nlm.nih.gov/pubmed/34080611 http://dx.doi.org/10.1093/cercor/bhab142 |
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author | Kushki, Azadeh Cardy, Robyn E Panahandeh, Sina Malihi, Mahan Hammill, Christopher Brian, Jessica Iaboni, Alana Taylor, Margot J Schachar, Russell Crosbie, Jennifer Arnold, Paul Kelley, Elizabeth Ayub, Muhammad Nicolson, Robert Georgiades, Stelios Lerch, Jason P Anagnostou, Evdokia |
author_facet | Kushki, Azadeh Cardy, Robyn E Panahandeh, Sina Malihi, Mahan Hammill, Christopher Brian, Jessica Iaboni, Alana Taylor, Margot J Schachar, Russell Crosbie, Jennifer Arnold, Paul Kelley, Elizabeth Ayub, Muhammad Nicolson, Robert Georgiades, Stelios Lerch, Jason P Anagnostou, Evdokia |
author_sort | Kushki, Azadeh |
collection | PubMed |
description | Social communication differences are seen in autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive–compulsive disorder (OCD), but the brain mechanisms contributing to these differences remain largely unknown. To address this gap, we used a data-driven and diagnosis-agnostic approach to discover brain correlates of social communication differences in ASD, ADHD, and OCD, and subgroups of individuals who share similar patterns of brain-behavior associations. A machine learning pipeline (regression clustering) was used to discover the pattern of association between structural brain measures (volume, surface area, and cortical thickness) and social communication abilities. Participants (n = 416) included children with a diagnosis of ASD (n = 192, age = 12.0[5.6], 19% female), ADHD (n = 109, age = 11.1[4.1], 18% female), or OCD (n = 50, age = 12.3[4.2], 42% female), and typically developing controls (n = 65, age = 11.6[7.1], 48% female). The analyses revealed (1) associations with social communication abilities in distributed cortical and subcortical networks implicated in social behaviors, language, attention, memory, and executive functions, and (2) three data-driven, diagnosis-agnostic subgroups based on the patterns of association in the above networks. Our results suggest that different brain networks may contribute to social communication differences in subgroups that are not diagnosis-specific. |
format | Online Article Text |
id | pubmed-8491692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-84916922021-10-06 Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences Kushki, Azadeh Cardy, Robyn E Panahandeh, Sina Malihi, Mahan Hammill, Christopher Brian, Jessica Iaboni, Alana Taylor, Margot J Schachar, Russell Crosbie, Jennifer Arnold, Paul Kelley, Elizabeth Ayub, Muhammad Nicolson, Robert Georgiades, Stelios Lerch, Jason P Anagnostou, Evdokia Cereb Cortex Original Article Social communication differences are seen in autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive–compulsive disorder (OCD), but the brain mechanisms contributing to these differences remain largely unknown. To address this gap, we used a data-driven and diagnosis-agnostic approach to discover brain correlates of social communication differences in ASD, ADHD, and OCD, and subgroups of individuals who share similar patterns of brain-behavior associations. A machine learning pipeline (regression clustering) was used to discover the pattern of association between structural brain measures (volume, surface area, and cortical thickness) and social communication abilities. Participants (n = 416) included children with a diagnosis of ASD (n = 192, age = 12.0[5.6], 19% female), ADHD (n = 109, age = 11.1[4.1], 18% female), or OCD (n = 50, age = 12.3[4.2], 42% female), and typically developing controls (n = 65, age = 11.6[7.1], 48% female). The analyses revealed (1) associations with social communication abilities in distributed cortical and subcortical networks implicated in social behaviors, language, attention, memory, and executive functions, and (2) three data-driven, diagnosis-agnostic subgroups based on the patterns of association in the above networks. Our results suggest that different brain networks may contribute to social communication differences in subgroups that are not diagnosis-specific. Oxford University Press 2021-06-03 /pmc/articles/PMC8491692/ /pubmed/34080611 http://dx.doi.org/10.1093/cercor/bhab142 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Article Kushki, Azadeh Cardy, Robyn E Panahandeh, Sina Malihi, Mahan Hammill, Christopher Brian, Jessica Iaboni, Alana Taylor, Margot J Schachar, Russell Crosbie, Jennifer Arnold, Paul Kelley, Elizabeth Ayub, Muhammad Nicolson, Robert Georgiades, Stelios Lerch, Jason P Anagnostou, Evdokia Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences |
title | Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences |
title_full | Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences |
title_fullStr | Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences |
title_full_unstemmed | Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences |
title_short | Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences |
title_sort | cross-diagnosis structural correlates of autistic-like social communication differences |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491692/ https://www.ncbi.nlm.nih.gov/pubmed/34080611 http://dx.doi.org/10.1093/cercor/bhab142 |
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