Cargando…

The Profile of Microbiological Pathogens in Diabetic Foot Ulcers

Diabetic foot, a main complication of diabetes mellitus, renders the foot susceptible to infection, and may eventually lead to non-traumatic limb amputation due to the deterioration of diabetic foot ulcers (DFUs). Characterizing the pathogen spectrum and antibiotic susceptibility is critical for the...

Descripción completa

Detalles Bibliográficos
Autores principales: Chai, Wei, Wang, Yuqing, Zheng, Huancheng, Yue, Song, Liu, Yan, Wu, Yili, Li, Xuezhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491778/
https://www.ncbi.nlm.nih.gov/pubmed/34621756
http://dx.doi.org/10.3389/fmed.2021.656467
_version_ 1784578795542413312
author Chai, Wei
Wang, Yuqing
Zheng, Huancheng
Yue, Song
Liu, Yan
Wu, Yili
Li, Xuezhi
author_facet Chai, Wei
Wang, Yuqing
Zheng, Huancheng
Yue, Song
Liu, Yan
Wu, Yili
Li, Xuezhi
author_sort Chai, Wei
collection PubMed
description Diabetic foot, a main complication of diabetes mellitus, renders the foot susceptible to infection, and may eventually lead to non-traumatic limb amputation due to the deterioration of diabetic foot ulcers (DFUs). Characterizing the pathogen spectrum and antibiotic susceptibility is critical for the effective treatment of DFUs. In the current study, the characteristics and antibiotic susceptibility of the pathogen spectrum were analyzed. Secretions from the DFUs of 102 patients were cultured, and dominant pathogens were identified by using test cards. Antibiotic susceptibility of dominant pathogens was assayed by the Kirby–Bauer assay. We found that the dominant pathogens varied with age, duration of diabetes, blood sugar control, and the initial cause of ulcers. Moreover, the dominant pathogens were susceptible to at least one antibiotic. However, the antibacterial efficacy of several commonly used antibiotics decreased from 2016 to 2019. Our study indicates that the identification of dominant pathogens and antibiotic susceptibility testing is essential for the treatment of DFUs with effective antibiotics, while the abuse of antibiotics should be strictly restrained to reduce the generation of antibiotic-resistant strains.
format Online
Article
Text
id pubmed-8491778
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84917782021-10-06 The Profile of Microbiological Pathogens in Diabetic Foot Ulcers Chai, Wei Wang, Yuqing Zheng, Huancheng Yue, Song Liu, Yan Wu, Yili Li, Xuezhi Front Med (Lausanne) Medicine Diabetic foot, a main complication of diabetes mellitus, renders the foot susceptible to infection, and may eventually lead to non-traumatic limb amputation due to the deterioration of diabetic foot ulcers (DFUs). Characterizing the pathogen spectrum and antibiotic susceptibility is critical for the effective treatment of DFUs. In the current study, the characteristics and antibiotic susceptibility of the pathogen spectrum were analyzed. Secretions from the DFUs of 102 patients were cultured, and dominant pathogens were identified by using test cards. Antibiotic susceptibility of dominant pathogens was assayed by the Kirby–Bauer assay. We found that the dominant pathogens varied with age, duration of diabetes, blood sugar control, and the initial cause of ulcers. Moreover, the dominant pathogens were susceptible to at least one antibiotic. However, the antibacterial efficacy of several commonly used antibiotics decreased from 2016 to 2019. Our study indicates that the identification of dominant pathogens and antibiotic susceptibility testing is essential for the treatment of DFUs with effective antibiotics, while the abuse of antibiotics should be strictly restrained to reduce the generation of antibiotic-resistant strains. Frontiers Media S.A. 2021-09-21 /pmc/articles/PMC8491778/ /pubmed/34621756 http://dx.doi.org/10.3389/fmed.2021.656467 Text en Copyright © 2021 Chai, Wang, Zheng, Yue, Liu, Wu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Chai, Wei
Wang, Yuqing
Zheng, Huancheng
Yue, Song
Liu, Yan
Wu, Yili
Li, Xuezhi
The Profile of Microbiological Pathogens in Diabetic Foot Ulcers
title The Profile of Microbiological Pathogens in Diabetic Foot Ulcers
title_full The Profile of Microbiological Pathogens in Diabetic Foot Ulcers
title_fullStr The Profile of Microbiological Pathogens in Diabetic Foot Ulcers
title_full_unstemmed The Profile of Microbiological Pathogens in Diabetic Foot Ulcers
title_short The Profile of Microbiological Pathogens in Diabetic Foot Ulcers
title_sort profile of microbiological pathogens in diabetic foot ulcers
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491778/
https://www.ncbi.nlm.nih.gov/pubmed/34621756
http://dx.doi.org/10.3389/fmed.2021.656467
work_keys_str_mv AT chaiwei theprofileofmicrobiologicalpathogensindiabeticfootulcers
AT wangyuqing theprofileofmicrobiologicalpathogensindiabeticfootulcers
AT zhenghuancheng theprofileofmicrobiologicalpathogensindiabeticfootulcers
AT yuesong theprofileofmicrobiologicalpathogensindiabeticfootulcers
AT liuyan theprofileofmicrobiologicalpathogensindiabeticfootulcers
AT wuyili theprofileofmicrobiologicalpathogensindiabeticfootulcers
AT lixuezhi theprofileofmicrobiologicalpathogensindiabeticfootulcers
AT chaiwei profileofmicrobiologicalpathogensindiabeticfootulcers
AT wangyuqing profileofmicrobiologicalpathogensindiabeticfootulcers
AT zhenghuancheng profileofmicrobiologicalpathogensindiabeticfootulcers
AT yuesong profileofmicrobiologicalpathogensindiabeticfootulcers
AT liuyan profileofmicrobiologicalpathogensindiabeticfootulcers
AT wuyili profileofmicrobiologicalpathogensindiabeticfootulcers
AT lixuezhi profileofmicrobiologicalpathogensindiabeticfootulcers