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The Profile of Microbiological Pathogens in Diabetic Foot Ulcers
Diabetic foot, a main complication of diabetes mellitus, renders the foot susceptible to infection, and may eventually lead to non-traumatic limb amputation due to the deterioration of diabetic foot ulcers (DFUs). Characterizing the pathogen spectrum and antibiotic susceptibility is critical for the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491778/ https://www.ncbi.nlm.nih.gov/pubmed/34621756 http://dx.doi.org/10.3389/fmed.2021.656467 |
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author | Chai, Wei Wang, Yuqing Zheng, Huancheng Yue, Song Liu, Yan Wu, Yili Li, Xuezhi |
author_facet | Chai, Wei Wang, Yuqing Zheng, Huancheng Yue, Song Liu, Yan Wu, Yili Li, Xuezhi |
author_sort | Chai, Wei |
collection | PubMed |
description | Diabetic foot, a main complication of diabetes mellitus, renders the foot susceptible to infection, and may eventually lead to non-traumatic limb amputation due to the deterioration of diabetic foot ulcers (DFUs). Characterizing the pathogen spectrum and antibiotic susceptibility is critical for the effective treatment of DFUs. In the current study, the characteristics and antibiotic susceptibility of the pathogen spectrum were analyzed. Secretions from the DFUs of 102 patients were cultured, and dominant pathogens were identified by using test cards. Antibiotic susceptibility of dominant pathogens was assayed by the Kirby–Bauer assay. We found that the dominant pathogens varied with age, duration of diabetes, blood sugar control, and the initial cause of ulcers. Moreover, the dominant pathogens were susceptible to at least one antibiotic. However, the antibacterial efficacy of several commonly used antibiotics decreased from 2016 to 2019. Our study indicates that the identification of dominant pathogens and antibiotic susceptibility testing is essential for the treatment of DFUs with effective antibiotics, while the abuse of antibiotics should be strictly restrained to reduce the generation of antibiotic-resistant strains. |
format | Online Article Text |
id | pubmed-8491778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84917782021-10-06 The Profile of Microbiological Pathogens in Diabetic Foot Ulcers Chai, Wei Wang, Yuqing Zheng, Huancheng Yue, Song Liu, Yan Wu, Yili Li, Xuezhi Front Med (Lausanne) Medicine Diabetic foot, a main complication of diabetes mellitus, renders the foot susceptible to infection, and may eventually lead to non-traumatic limb amputation due to the deterioration of diabetic foot ulcers (DFUs). Characterizing the pathogen spectrum and antibiotic susceptibility is critical for the effective treatment of DFUs. In the current study, the characteristics and antibiotic susceptibility of the pathogen spectrum were analyzed. Secretions from the DFUs of 102 patients were cultured, and dominant pathogens were identified by using test cards. Antibiotic susceptibility of dominant pathogens was assayed by the Kirby–Bauer assay. We found that the dominant pathogens varied with age, duration of diabetes, blood sugar control, and the initial cause of ulcers. Moreover, the dominant pathogens were susceptible to at least one antibiotic. However, the antibacterial efficacy of several commonly used antibiotics decreased from 2016 to 2019. Our study indicates that the identification of dominant pathogens and antibiotic susceptibility testing is essential for the treatment of DFUs with effective antibiotics, while the abuse of antibiotics should be strictly restrained to reduce the generation of antibiotic-resistant strains. Frontiers Media S.A. 2021-09-21 /pmc/articles/PMC8491778/ /pubmed/34621756 http://dx.doi.org/10.3389/fmed.2021.656467 Text en Copyright © 2021 Chai, Wang, Zheng, Yue, Liu, Wu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Chai, Wei Wang, Yuqing Zheng, Huancheng Yue, Song Liu, Yan Wu, Yili Li, Xuezhi The Profile of Microbiological Pathogens in Diabetic Foot Ulcers |
title | The Profile of Microbiological Pathogens in Diabetic Foot Ulcers |
title_full | The Profile of Microbiological Pathogens in Diabetic Foot Ulcers |
title_fullStr | The Profile of Microbiological Pathogens in Diabetic Foot Ulcers |
title_full_unstemmed | The Profile of Microbiological Pathogens in Diabetic Foot Ulcers |
title_short | The Profile of Microbiological Pathogens in Diabetic Foot Ulcers |
title_sort | profile of microbiological pathogens in diabetic foot ulcers |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491778/ https://www.ncbi.nlm.nih.gov/pubmed/34621756 http://dx.doi.org/10.3389/fmed.2021.656467 |
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