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Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism

BACKGROUND: We aimed to identify the relationship between metabolically healthy obesity (MHO), a special subtype of obesity, and the incidence of cardiovascular disease (CVD) in rural Xinjiang. METHODS: Body mass index (BMI) and the Joint Interim Statement criteria were utilized to define obesity an...

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Autores principales: Wang, Wenqiang, He, Jia, Hu, Yunhua, Song, Yanpeng, Zhang, Xianghui, Guo, Heng, Wang, Xinping, Keerman, Mulatibieke, Ma, Jiaolong, Yan, Yizhong, Zhang, Jingyu, Ma, Rulin, Guo, Shuxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491784/
https://www.ncbi.nlm.nih.gov/pubmed/34621129
http://dx.doi.org/10.2147/DMSO.S330212
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author Wang, Wenqiang
He, Jia
Hu, Yunhua
Song, Yanpeng
Zhang, Xianghui
Guo, Heng
Wang, Xinping
Keerman, Mulatibieke
Ma, Jiaolong
Yan, Yizhong
Zhang, Jingyu
Ma, Rulin
Guo, Shuxia
author_facet Wang, Wenqiang
He, Jia
Hu, Yunhua
Song, Yanpeng
Zhang, Xianghui
Guo, Heng
Wang, Xinping
Keerman, Mulatibieke
Ma, Jiaolong
Yan, Yizhong
Zhang, Jingyu
Ma, Rulin
Guo, Shuxia
author_sort Wang, Wenqiang
collection PubMed
description BACKGROUND: We aimed to identify the relationship between metabolically healthy obesity (MHO), a special subtype of obesity, and the incidence of cardiovascular disease (CVD) in rural Xinjiang. METHODS: Body mass index (BMI) and the Joint Interim Statement criteria were utilized to define obesity and metabolic status, respectively. A baseline survey was conducted between 2010 and 2012. The cohort was followed-up until 2017, including 5059 participants (2953 Uyghurs and 2106 Kazakhs) in the analysis. RESULTS: During 6.78 years of follow-up, 471 individuals developed CVD, 10.8% (n=545) of whom were obese, and the prevalence of MHO and MHNW was 5.2% and 54.5%, respectively. Compared with metabolically healthy normal weight subjects, the subjects with MHO had an increased risk of CVD (hazard ratio [HR]=1.76, 95% confidence interval [CI]: 1.23−2.51), while the metabolically unhealthy obesity (MUO) group had an even higher risk (HR=3.80, 95% CI: 2.87−5.03). Additionally, there were sex differences in the relationship between BMI-metabolic status and incident CVD (P(interaction) =0.027). Compared with the subjects with MHO, those with MUO had an increased risk of CVD (HR=1.84, 95% CI: 1.26−2.71). CONCLUSION: MHO was associated with a high risk of CVD among adults in rural Xinjiang. In each BMI category, metabolically unhealthy subjects had a higher risk of developing CVD than did metabolically healthy subjects.
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spelling pubmed-84917842021-10-06 Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism Wang, Wenqiang He, Jia Hu, Yunhua Song, Yanpeng Zhang, Xianghui Guo, Heng Wang, Xinping Keerman, Mulatibieke Ma, Jiaolong Yan, Yizhong Zhang, Jingyu Ma, Rulin Guo, Shuxia Diabetes Metab Syndr Obes Original Research BACKGROUND: We aimed to identify the relationship between metabolically healthy obesity (MHO), a special subtype of obesity, and the incidence of cardiovascular disease (CVD) in rural Xinjiang. METHODS: Body mass index (BMI) and the Joint Interim Statement criteria were utilized to define obesity and metabolic status, respectively. A baseline survey was conducted between 2010 and 2012. The cohort was followed-up until 2017, including 5059 participants (2953 Uyghurs and 2106 Kazakhs) in the analysis. RESULTS: During 6.78 years of follow-up, 471 individuals developed CVD, 10.8% (n=545) of whom were obese, and the prevalence of MHO and MHNW was 5.2% and 54.5%, respectively. Compared with metabolically healthy normal weight subjects, the subjects with MHO had an increased risk of CVD (hazard ratio [HR]=1.76, 95% confidence interval [CI]: 1.23−2.51), while the metabolically unhealthy obesity (MUO) group had an even higher risk (HR=3.80, 95% CI: 2.87−5.03). Additionally, there were sex differences in the relationship between BMI-metabolic status and incident CVD (P(interaction) =0.027). Compared with the subjects with MHO, those with MUO had an increased risk of CVD (HR=1.84, 95% CI: 1.26−2.71). CONCLUSION: MHO was associated with a high risk of CVD among adults in rural Xinjiang. In each BMI category, metabolically unhealthy subjects had a higher risk of developing CVD than did metabolically healthy subjects. Dove 2021-10-01 /pmc/articles/PMC8491784/ /pubmed/34621129 http://dx.doi.org/10.2147/DMSO.S330212 Text en © 2021 Wang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Wang, Wenqiang
He, Jia
Hu, Yunhua
Song, Yanpeng
Zhang, Xianghui
Guo, Heng
Wang, Xinping
Keerman, Mulatibieke
Ma, Jiaolong
Yan, Yizhong
Zhang, Jingyu
Ma, Rulin
Guo, Shuxia
Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism
title Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism
title_full Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism
title_fullStr Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism
title_full_unstemmed Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism
title_short Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism
title_sort comparison of the incidence of cardiovascular diseases in weight groups with healthy and unhealthy metabolism
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491784/
https://www.ncbi.nlm.nih.gov/pubmed/34621129
http://dx.doi.org/10.2147/DMSO.S330212
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