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Condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals

Understanding mortality, derived from debilitations consisting of multiple diseases, is crucial for patient stratification. Here, in systematic fashion, we report comprehensive mortality data that map the temporal correlation of diseases that tend toward deaths in hospitals. We used a mortality traj...

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Autores principales: Paik, Hyojung, Kim, Jimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491897/
https://www.ncbi.nlm.nih.gov/pubmed/34610032
http://dx.doi.org/10.1371/journal.pone.0257894
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author Paik, Hyojung
Kim, Jimin
author_facet Paik, Hyojung
Kim, Jimin
author_sort Paik, Hyojung
collection PubMed
description Understanding mortality, derived from debilitations consisting of multiple diseases, is crucial for patient stratification. Here, in systematic fashion, we report comprehensive mortality data that map the temporal correlation of diseases that tend toward deaths in hospitals. We used a mortality trajectory model that represents the temporal ordering of disease appearance, with strong correlations, that terminated in fatal outcomes from one initial diagnosis in a set of patients throughout multiple admissions. Based on longitudinal healthcare records of 10.4 million patients from over 350 hospitals, we profiled 300 mortality trajectories, starting from 118 diseases, in 311,309 patients. Three-quarters (75%) of 59,794 end-stage patients and their deaths accrued throughout 160,360 multiple disease appearances in a short-term period (<4 years, 3.5 diseases per patient). This overlooked and substantial heterogeneity of disease patients and outcomes in the real world is unraveled in our trajectory map at the disease-wide level. For example, the converged dead-end in our trajectory map presents an extreme diversity of sepsis patients based on 43 prior diseases, including lymphoma and cardiac diseases. The trajectories involving the largest number of deaths for each age group highlight the essential predisposing diseases, such as acute myocardial infarction and liver cirrhosis, which lead to over 14,000 deaths. In conclusion, the deciphering of the debilitation processes of patients, consisting of the temporal correlations of diseases that tend towards hospital death at a population-wide level is feasible.
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spelling pubmed-84918972021-10-06 Condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals Paik, Hyojung Kim, Jimin PLoS One Research Article Understanding mortality, derived from debilitations consisting of multiple diseases, is crucial for patient stratification. Here, in systematic fashion, we report comprehensive mortality data that map the temporal correlation of diseases that tend toward deaths in hospitals. We used a mortality trajectory model that represents the temporal ordering of disease appearance, with strong correlations, that terminated in fatal outcomes from one initial diagnosis in a set of patients throughout multiple admissions. Based on longitudinal healthcare records of 10.4 million patients from over 350 hospitals, we profiled 300 mortality trajectories, starting from 118 diseases, in 311,309 patients. Three-quarters (75%) of 59,794 end-stage patients and their deaths accrued throughout 160,360 multiple disease appearances in a short-term period (<4 years, 3.5 diseases per patient). This overlooked and substantial heterogeneity of disease patients and outcomes in the real world is unraveled in our trajectory map at the disease-wide level. For example, the converged dead-end in our trajectory map presents an extreme diversity of sepsis patients based on 43 prior diseases, including lymphoma and cardiac diseases. The trajectories involving the largest number of deaths for each age group highlight the essential predisposing diseases, such as acute myocardial infarction and liver cirrhosis, which lead to over 14,000 deaths. In conclusion, the deciphering of the debilitation processes of patients, consisting of the temporal correlations of diseases that tend towards hospital death at a population-wide level is feasible. Public Library of Science 2021-10-05 /pmc/articles/PMC8491897/ /pubmed/34610032 http://dx.doi.org/10.1371/journal.pone.0257894 Text en © 2021 Paik, Kim https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Paik, Hyojung
Kim, Jimin
Condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals
title Condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals
title_full Condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals
title_fullStr Condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals
title_full_unstemmed Condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals
title_short Condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals
title_sort condensed trajectory of the temporal correlation of diseases and mortality extracted from over 300,000 patients in hospitals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491897/
https://www.ncbi.nlm.nih.gov/pubmed/34610032
http://dx.doi.org/10.1371/journal.pone.0257894
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