Membrane-binding mechanism of the EEA1 FYVE domain revealed by multi-scale molecular dynamics simulations

Early Endosomal Antigen 1 (EEA1) is a key protein in endosomal trafficking and is implicated in both autoimmune and neurological diseases. The C-terminal FYVE domain of EEA1 binds endosomal membranes, which contain phosphatidylinositol-3-phosphate (PI(3)P). Although it is known that FYVE binds PI(3)...

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Detalles Bibliográficos
Autores principales: Larsen, Andreas Haahr, Tata, Lilya, John, Laura H., Sansom, Mark S. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491906/
https://www.ncbi.nlm.nih.gov/pubmed/34555023
http://dx.doi.org/10.1371/journal.pcbi.1008807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491906/
https://www.ncbi.nlm.nih.gov/pubmed/34555023
http://dx.doi.org/10.1371/journal.pcbi.1008807

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