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A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States
BACKGROUND: COVID-19 vaccines were efficacious and safe in clinical trials. We report nine events of acute pericarditis (AP) in eight patients following COVID-19 vaccination with BNT162b2 (6/9), AZD1222 (2/9) and mRNA-1273 (1/9). METHODS: All patients were referred for AP temporally linked with COVI...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491922/ https://www.ncbi.nlm.nih.gov/pubmed/34635376 http://dx.doi.org/10.1016/j.vaccine.2021.09.078 |
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author | Lazaros, George Anastassopoulou, Cleo Hatziantoniou, Sophia Kalos, Theodoros Soulaidopoulos, Stergios Lazarou, Emilia Vlachopoulos, Charalambos Vassilopoulos, Dimitrios Tsakris, Athanasios Tsioufis, Costas |
author_facet | Lazaros, George Anastassopoulou, Cleo Hatziantoniou, Sophia Kalos, Theodoros Soulaidopoulos, Stergios Lazarou, Emilia Vlachopoulos, Charalambos Vassilopoulos, Dimitrios Tsakris, Athanasios Tsioufis, Costas |
author_sort | Lazaros, George |
collection | PubMed |
description | BACKGROUND: COVID-19 vaccines were efficacious and safe in clinical trials. We report nine events of acute pericarditis (AP) in eight patients following COVID-19 vaccination with BNT162b2 (6/9), AZD1222 (2/9) and mRNA-1273 (1/9). METHODS: All patients were referred for AP temporally linked with COVID-19 vaccination. Chest pain was the most common clinical manifestation. Alternative etiologies were excluded upon thorough diagnostic work up. AP diagnosis was established according to ESC guidelines. FINDINGS: Five events occurred after the first vaccine dose and four after the second. The mean age in this cohort was 65.8 ± 10.2 years and the men/women ratio 3/5. All events resolved without sequelae; two events were complicated by cardiac tamponade requiring emergent pericardial decompression. Hospitalization was required in four cases. INTERPRETATION: Although causality cannot be firmly established, AP has emerged as a possible complication following COVID-19 vaccination. Further investigation is indispensable to fully characterize this new entity. |
format | Online Article Text |
id | pubmed-8491922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84919222021-10-06 A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States Lazaros, George Anastassopoulou, Cleo Hatziantoniou, Sophia Kalos, Theodoros Soulaidopoulos, Stergios Lazarou, Emilia Vlachopoulos, Charalambos Vassilopoulos, Dimitrios Tsakris, Athanasios Tsioufis, Costas Vaccine Short Communication BACKGROUND: COVID-19 vaccines were efficacious and safe in clinical trials. We report nine events of acute pericarditis (AP) in eight patients following COVID-19 vaccination with BNT162b2 (6/9), AZD1222 (2/9) and mRNA-1273 (1/9). METHODS: All patients were referred for AP temporally linked with COVID-19 vaccination. Chest pain was the most common clinical manifestation. Alternative etiologies were excluded upon thorough diagnostic work up. AP diagnosis was established according to ESC guidelines. FINDINGS: Five events occurred after the first vaccine dose and four after the second. The mean age in this cohort was 65.8 ± 10.2 years and the men/women ratio 3/5. All events resolved without sequelae; two events were complicated by cardiac tamponade requiring emergent pericardial decompression. Hospitalization was required in four cases. INTERPRETATION: Although causality cannot be firmly established, AP has emerged as a possible complication following COVID-19 vaccination. Further investigation is indispensable to fully characterize this new entity. Elsevier Ltd. 2021-10-29 2021-10-05 /pmc/articles/PMC8491922/ /pubmed/34635376 http://dx.doi.org/10.1016/j.vaccine.2021.09.078 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Short Communication Lazaros, George Anastassopoulou, Cleo Hatziantoniou, Sophia Kalos, Theodoros Soulaidopoulos, Stergios Lazarou, Emilia Vlachopoulos, Charalambos Vassilopoulos, Dimitrios Tsakris, Athanasios Tsioufis, Costas A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States |
title | A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States |
title_full | A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States |
title_fullStr | A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States |
title_full_unstemmed | A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States |
title_short | A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States |
title_sort | case series of acute pericarditis following covid-19 vaccination in the context of recent reports from europe and the united states |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491922/ https://www.ncbi.nlm.nih.gov/pubmed/34635376 http://dx.doi.org/10.1016/j.vaccine.2021.09.078 |
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