Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin (PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is characterized by TDP-43 inclusions and neuroinflammation, but how PGRN loss causes disease remains elusive. We show that Grn knockout...

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Detalles Bibliográficos
Autores principales: Wu, Yanwei, Shao, Wei, Todd, Tiffany W., Tong, Jimei, Yue, Mei, Koga, Shunsuke, Castanedes-Casey, Monica, Librero, Ariston L., Lee, Chris W., Mackenzie, Ian R., Dickson, Dennis W., Zhang, Yong-Jie, Petrucelli, Leonard, Prudencio, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491969/
https://www.ncbi.nlm.nih.gov/pubmed/34433069
http://dx.doi.org/10.1016/j.celrep.2021.109581

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