Cargando…

End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

Preferably, lifespan-extending therapies should work when applied late in life without causing undesired pathologies. Reducing insulin/insulin-like growth factor (IGF)-1 signaling (IIS) increases lifespan across species, but the effects of reduced IIS interventions in extreme geriatric ages remains...

Descripción completa

Detalles Bibliográficos
Autores principales:	Venz, Richard, Pekec, Tina, Katic, Iskra, Ciosk, Rafal, Ewald, Collin Yvès
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492056/ https://www.ncbi.nlm.nih.gov/pubmed/34505574 http://dx.doi.org/10.7554/eLife.71335

Ejemplares similares

Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling
por: Qi, Zhimin, et al.
Publicado: (2021)

CRISPR/Cas9 Genome Editing in Caenorhabditis elegans: Evaluation of Templates for Homology-Mediated Repair and Knock-Ins by Homology-Independent DNA Repair
por: Katic, Iskra, et al.
Publicado: (2015)

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
por: Ewald, Collin Y., et al.
Publicado: (2014)

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans
por: Ewald, Collin Yvès, et al.
Publicado: (2017)

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
por: Son, Heehwa G., et al.
Publicado: (2017)

Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote C. elegans Longevity and Healthspan
por: Ji, Huihui, et al.
Publicado: (2021)

DAF-16 and PQM-1: Partners in longevity
por: Tepper, Ronald G., et al.
Publicado: (2014)

DAF-16/FOXO Transcription Factor in Aging and Longevity
por: Sun, Xiaojuan, et al.
Publicado: (2017)

Divergent Mechanisms Controlling Hypoxic Sensitivity and Lifespan by the DAF-2/Insulin/IGF-Receptor Pathway
por: Mabon, Meghann E., et al.
Publicado: (2009)

Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans
por: Venz, Richard, et al.
Publicado: (2020)

DAF-21/Hsp90 is required for C. elegans longevity by ensuring DAF-16/FOXO isoform A function
por: Somogyvári, Milán, et al.
Publicado: (2018)

Human insulin/IGF-1 and familial longevity at middle age
por: Rozing, Maarten P., et al.
Publicado: (2009)

Freeze–thaw Caenorhabditis elegans freeze–thaw stress response is regulated by the insulin/IGF-1 receptor daf-2
por: Hu, Jian-Ping, et al.
Publicado: (2015)

Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism
por: Stout, Gerdine J, et al.
Publicado: (2013)

Dianxianning improved amyloid β-induced pathological characteristics partially through DAF-2/DAF-16 insulin like pathway in transgenic C. elegans
por: Zhi, Dejuan, et al.
Publicado: (2017)

Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator
por: Li, Ji, et al.
Publicado: (2008)

Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF‐16‐induced longevity
por: McIntyre, Rebecca L., et al.
Publicado: (2021)

DAF‐2/insulin IGF‐1 receptor regulates motility during aging by integrating opposite signaling from muscle and neuronal tissues
por: Roy, Charline, et al.
Publicado: (2022)

Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill
por: Ewald, Collin Y.
Publicado: (2021)

DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO
por: Schuster, Eugene, et al.
Publicado: (2010)

DAF-16/FOXO employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity
por: Riedel, Christian G., et al.
Publicado: (2013)

Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson’s disease
por: Haque, Rizwanul, et al.
Publicado: (2020)

A chromatin modifier integrates insulin/IGF‐1 signalling and dietary restriction to regulate longevity
por: Singh, Anupama, et al.
Publicado: (2016)

Regulation of Longevity by Insulin/Igf-1 Signaling, Sensory Neurons and the Germline in the Nematode C. Elegans
por: Kenyon, Cynthia
Publicado: (2001)

The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster
por: Altintas, Ozlem, et al.
Publicado: (2016)

Social Chemical Communication Determines Recovery From L1 Arrest via DAF-16 Activation
por: Mata-Cabana, Alejandro, et al.
Publicado: (2020)

Longevity interventions temporally scale healthspan in Caenorhabditis elegans
por: Statzer, Cyril, et al.
Publicado: (2022)

Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans
por: Chen, Albert Tzong-Yang, et al.
Publicado: (2015)

Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF‐16 in C. elegans
por: Xu, Aiping, et al.
Publicado: (2019)

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
por: Lin, Xin-Xuan, et al.
Publicado: (2018)

The Transcription Factor DAF-16 is Essential for Increased Longevity in C. elegans Exposed to Bifidobacterium longum BB68
por: Zhao, Liang, et al.
Publicado: (2017)

DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes
por: Sen, Ilke, et al.
Publicado: (2020)

Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF‐16/FOXO
por: Park, Sangsoon, et al.
Publicado: (2020)

Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons
por: Pekec, Tina, et al.
Publicado: (2022)

Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes
por: Arnold, Andreas, et al.
Publicado: (2014)

Mitochondrial Function Is Required for Secretion of DAF-28/Insulin in C. elegans
por: Billing, Ola, et al.
Publicado: (2011)

Caenorhabditis elegans DAF-2 as a Model for Human Insulin Receptoropathies
por: Bulger, David A., et al.
Publicado: (2016)

The daf-2 insulin receptor functions in C. elegans embryo elongation
por: Suresh, Annu, et al.
Publicado: (2020)

LC–MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism
por: Depuydt, Geert, et al.
Publicado: (2014)

Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant
por: Depuydt, Geert, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0c0rru45kmsh411nlm8fpehq31