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Information content differentiates enhancers from silencers in mouse photoreceptors

Enhancers and silencers often depend on the same transcription factors (TFs) and are conflated in genomic assays of TF binding or chromatin state. To identify sequence features that distinguish enhancers and silencers, we assayed massively parallel reporter libraries of genomic sequences targeted by...

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Detalles Bibliográficos
Autores principales:	Friedman, Ryan Z, Granas, David M, Myers, Connie A, Corbo, Joseph C, Cohen, Barak A, White, Michael A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492058/ https://www.ncbi.nlm.nih.gov/pubmed/34486522 http://dx.doi.org/10.7554/eLife.67403

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