Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial

We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resi...

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Detalles Bibliográficos
Autores principales: Arzika, Ahmed M, Maliki, Ramatou, Abdou, Amza, Mankara, Alio K, Harouna, Abdoul N, Cook, Catherine, Hinterwirth, Armin, Worden, Lee, Zhong, Lina, Chen, Cindi, Ruder, Kevin, Zhou, Zhaoxia, Lebas, Elodie, O’Brien, Kieran S, Oldenburg, Catherine E, Le, Victoria, Arnold, Benjamin F, Porco, Travis C, Keenan, Jeremy D, Lietman, Thomas M, Doan, Thuy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492121/
https://www.ncbi.nlm.nih.gov/pubmed/34037753
http://dx.doi.org/10.1093/cid/ciab485
Descripción
Sumario:We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs. CLINICAL TRIALS REGISTRATION: NCT02047981

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