Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial

We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resi...

Descripción completa

Detalles Bibliográficos
Autores principales: Arzika, Ahmed M, Maliki, Ramatou, Abdou, Amza, Mankara, Alio K, Harouna, Abdoul N, Cook, Catherine, Hinterwirth, Armin, Worden, Lee, Zhong, Lina, Chen, Cindi, Ruder, Kevin, Zhou, Zhaoxia, Lebas, Elodie, O’Brien, Kieran S, Oldenburg, Catherine E, Le, Victoria, Arnold, Benjamin F, Porco, Travis C, Keenan, Jeremy D, Lietman, Thomas M, Doan, Thuy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492121/
https://www.ncbi.nlm.nih.gov/pubmed/34037753
http://dx.doi.org/10.1093/cid/ciab485
_version_ 1784578866626428928
author Arzika, Ahmed M
Maliki, Ramatou
Abdou, Amza
Mankara, Alio K
Harouna, Abdoul N
Cook, Catherine
Hinterwirth, Armin
Worden, Lee
Zhong, Lina
Chen, Cindi
Ruder, Kevin
Zhou, Zhaoxia
Lebas, Elodie
O’Brien, Kieran S
Oldenburg, Catherine E
Le, Victoria
Arnold, Benjamin F
Porco, Travis C
Keenan, Jeremy D
Lietman, Thomas M
Doan, Thuy
author_facet Arzika, Ahmed M
Maliki, Ramatou
Abdou, Amza
Mankara, Alio K
Harouna, Abdoul N
Cook, Catherine
Hinterwirth, Armin
Worden, Lee
Zhong, Lina
Chen, Cindi
Ruder, Kevin
Zhou, Zhaoxia
Lebas, Elodie
O’Brien, Kieran S
Oldenburg, Catherine E
Le, Victoria
Arnold, Benjamin F
Porco, Travis C
Keenan, Jeremy D
Lietman, Thomas M
Doan, Thuy
author_sort Arzika, Ahmed M
collection PubMed
description We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs. CLINICAL TRIALS REGISTRATION: NCT02047981
format Online
Article
Text
id pubmed-8492121
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-84921212021-10-06 Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial Arzika, Ahmed M Maliki, Ramatou Abdou, Amza Mankara, Alio K Harouna, Abdoul N Cook, Catherine Hinterwirth, Armin Worden, Lee Zhong, Lina Chen, Cindi Ruder, Kevin Zhou, Zhaoxia Lebas, Elodie O’Brien, Kieran S Oldenburg, Catherine E Le, Victoria Arnold, Benjamin F Porco, Travis C Keenan, Jeremy D Lietman, Thomas M Doan, Thuy Clin Infect Dis Brief Reports We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs. CLINICAL TRIALS REGISTRATION: NCT02047981 Oxford University Press 2021-05-26 /pmc/articles/PMC8492121/ /pubmed/34037753 http://dx.doi.org/10.1093/cid/ciab485 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Arzika, Ahmed M
Maliki, Ramatou
Abdou, Amza
Mankara, Alio K
Harouna, Abdoul N
Cook, Catherine
Hinterwirth, Armin
Worden, Lee
Zhong, Lina
Chen, Cindi
Ruder, Kevin
Zhou, Zhaoxia
Lebas, Elodie
O’Brien, Kieran S
Oldenburg, Catherine E
Le, Victoria
Arnold, Benjamin F
Porco, Travis C
Keenan, Jeremy D
Lietman, Thomas M
Doan, Thuy
Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial
title Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial
title_full Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial
title_fullStr Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial
title_full_unstemmed Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial
title_short Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial
title_sort gut resistome of preschool children after prolonged mass azithromycin distribution: a cluster-randomized trial
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492121/
https://www.ncbi.nlm.nih.gov/pubmed/34037753
http://dx.doi.org/10.1093/cid/ciab485
work_keys_str_mv AT arzikaahmedm gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT malikiramatou gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT abdouamza gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT mankaraaliok gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT harounaabdouln gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT cookcatherine gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT hinterwirtharmin gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT wordenlee gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT zhonglina gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT chencindi gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT ruderkevin gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT zhouzhaoxia gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT lebaselodie gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT obrienkierans gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT oldenburgcatherinee gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT levictoria gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT arnoldbenjaminf gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT porcotravisc gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT keenanjeremyd gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT lietmanthomasm gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial
AT doanthuy gutresistomeofpreschoolchildrenafterprolongedmassazithromycindistributionaclusterrandomizedtrial

Ejemplares similares