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Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases
Mesenchymal stem cells (MSCs) are the most exploited stem cells with multilineage differentiation potential and immunomodulatory properties. Numerous lines of findings have reported their successful applications in a multitude of inflammatory conditions and immune disorders. However, it is currently...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492257/ https://www.ncbi.nlm.nih.gov/pubmed/34621464 http://dx.doi.org/10.1155/2021/4539453 |
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author | Shen, Min Chen, Tong |
author_facet | Shen, Min Chen, Tong |
author_sort | Shen, Min |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) are the most exploited stem cells with multilineage differentiation potential and immunomodulatory properties. Numerous lines of findings have reported their successful applications in a multitude of inflammatory conditions and immune disorders. However, it is currently discovered that these effects are mainly mediated in a paracrine manner by MSC-exosomes. Moreover, MSC-exosomes have been implicated in a wide variety of biological responses including immunomodulation, oxidative stress, tumor progression, and tissue regeneration. Meanwhile, they are reported to actively participate in various hematological diseases by the means of transferring different types of exosomal components to the target cells. Therefore, in this review, we briefly discuss the sources and biological features of MSCs and then illustrate the biogenesis and biological processes of MSC-exosomes. Of note, this paper especially highlights the latest research progress of MSC-exosomes in hematological diseases. |
format | Online Article Text |
id | pubmed-8492257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-84922572021-10-06 Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases Shen, Min Chen, Tong Oxid Med Cell Longev Review Article Mesenchymal stem cells (MSCs) are the most exploited stem cells with multilineage differentiation potential and immunomodulatory properties. Numerous lines of findings have reported their successful applications in a multitude of inflammatory conditions and immune disorders. However, it is currently discovered that these effects are mainly mediated in a paracrine manner by MSC-exosomes. Moreover, MSC-exosomes have been implicated in a wide variety of biological responses including immunomodulation, oxidative stress, tumor progression, and tissue regeneration. Meanwhile, they are reported to actively participate in various hematological diseases by the means of transferring different types of exosomal components to the target cells. Therefore, in this review, we briefly discuss the sources and biological features of MSCs and then illustrate the biogenesis and biological processes of MSC-exosomes. Of note, this paper especially highlights the latest research progress of MSC-exosomes in hematological diseases. Hindawi 2021-09-28 /pmc/articles/PMC8492257/ /pubmed/34621464 http://dx.doi.org/10.1155/2021/4539453 Text en Copyright © 2021 Min Shen and Tong Chen. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Shen, Min Chen, Tong Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title | Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_full | Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_fullStr | Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_full_unstemmed | Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_short | Mesenchymal Stem Cell-Derived Exosomes and Their Potential Agents in Hematological Diseases |
title_sort | mesenchymal stem cell-derived exosomes and their potential agents in hematological diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492257/ https://www.ncbi.nlm.nih.gov/pubmed/34621464 http://dx.doi.org/10.1155/2021/4539453 |
work_keys_str_mv | AT shenmin mesenchymalstemcellderivedexosomesandtheirpotentialagentsinhematologicaldiseases AT chentong mesenchymalstemcellderivedexosomesandtheirpotentialagentsinhematologicaldiseases |