Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-k...

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Autores principales: Vyavahare, Sagar, Kumar, Sandeep, Cantu, Nicholas, Kolhe, Ravindra, Bollag, Wendy B., McGee-Lawrence, Meghan E., Hill, William D., Hamrick, Mark W., Isales, Carlos M., Fulzele, Sadanand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492288/
https://www.ncbi.nlm.nih.gov/pubmed/34621138
http://dx.doi.org/10.1155/2021/2911578
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author Vyavahare, Sagar
Kumar, Sandeep
Cantu, Nicholas
Kolhe, Ravindra
Bollag, Wendy B.
McGee-Lawrence, Meghan E.
Hill, William D.
Hamrick, Mark W.
Isales, Carlos M.
Fulzele, Sadanand
author_facet Vyavahare, Sagar
Kumar, Sandeep
Cantu, Nicholas
Kolhe, Ravindra
Bollag, Wendy B.
McGee-Lawrence, Meghan E.
Hill, William D.
Hamrick, Mark W.
Isales, Carlos M.
Fulzele, Sadanand
author_sort Vyavahare, Sagar
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, and musculoskeletal system biology. In this minireview, we surmise the effects of the kynurenine pathway in COVID-19 patients and how this pathway might impact muscle and bone biology.
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spelling pubmed-84922882021-10-06 Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview Vyavahare, Sagar Kumar, Sandeep Cantu, Nicholas Kolhe, Ravindra Bollag, Wendy B. McGee-Lawrence, Meghan E. Hill, William D. Hamrick, Mark W. Isales, Carlos M. Fulzele, Sadanand Mediators Inflamm Review Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, and musculoskeletal system biology. In this minireview, we surmise the effects of the kynurenine pathway in COVID-19 patients and how this pathway might impact muscle and bone biology. Hindawi 2021-10-05 /pmc/articles/PMC8492288/ /pubmed/34621138 http://dx.doi.org/10.1155/2021/2911578 Text en Copyright © 2021 Sagar Vyavahare et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vyavahare, Sagar
Kumar, Sandeep
Cantu, Nicholas
Kolhe, Ravindra
Bollag, Wendy B.
McGee-Lawrence, Meghan E.
Hill, William D.
Hamrick, Mark W.
Isales, Carlos M.
Fulzele, Sadanand
Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
title Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
title_full Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
title_fullStr Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
title_full_unstemmed Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
title_short Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
title_sort tryptophan-kynurenine pathway in covid-19-dependent musculoskeletal pathology: a minireview
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492288/
https://www.ncbi.nlm.nih.gov/pubmed/34621138
http://dx.doi.org/10.1155/2021/2911578
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