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Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis

Kawasaki disease (KD) is the leading cause of acquired heart disease among children. Murine and human data suggest that the NLRP3–IL-1β pathway is the main driver of KD pathophysiology. NLRP3 can be activated during defective autophagy/mitophagy. We used the Lactobacillus casei cell wall extract (LC...

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Detalles Bibliográficos
Autores principales:	Marek-Iannucci, Stefanie, Ozdemir, Asli B., Moreira, Debbie, Gomez, Angela C., Lane, Malcolm, Porritt, Rebecca A., Lee, Youngho, Shimada, Kenichi, Abe, Masanori, Stotland, Aleksandr, Zemmour, David, Parker, Sarah, Sanchez-Lopez, Elsa, Van Eyk, Jennifer, Gottlieb, Roberta A., Fishbein, Michael C., Karin, Michael, Crother, Timothy R., Rivas, Magali Noval, Arditi, Moshe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492304/ https://www.ncbi.nlm.nih.gov/pubmed/34403365 http://dx.doi.org/10.1172/jci.insight.151981

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