NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity

The NR4A family of orphan nuclear receptors (Nr4a1–3) plays redundant roles to establish and maintain Treg identity; deletion of multiple family members in the thymus results in Treg deficiency and a severe inflammatory disease. Consequently, it has been challenging to unmask redundant functions of...

Descripción completa

Detalles Bibliográficos
Autores principales: Hiwa, Ryosuke, Nielsen, Hailyn V., Mueller, James L., Mandla, Ravi, Zikherman, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492309/
https://www.ncbi.nlm.nih.gov/pubmed/34343134
http://dx.doi.org/10.1172/jci.insight.151005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492309/
https://www.ncbi.nlm.nih.gov/pubmed/34343134
http://dx.doi.org/10.1172/jci.insight.151005

Ejemplares similares