Ghrelin cell–expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin

Mechanisms underlying postprandial and obesity-associated plasma ghrelin reductions are incompletely understood. Here, using ghrelin cell–selective insulin receptor–KO (GhIRKO) mice, we tested the impact of insulin, acting via ghrelin cell–expressed insulin receptors (IRs), to suppress ghrelin secre...

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Detalles Bibliográficos
Autores principales: Shankar, Kripa, Takemi, Shota, Gupta, Deepali, Varshney, Salil, Mani, Bharath K., Osborne-Lawrence, Sherri, Metzger, Nathan P., Richard, Corine P., Berglund, Eric D., Zigman, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492315/
https://www.ncbi.nlm.nih.gov/pubmed/34473648
http://dx.doi.org/10.1172/jci.insight.146983

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