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Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide

Neutrophil-mediated activation and injury of the endothelium play roles in the pathogenesis of diverse disease states ranging from autoimmunity to cancer to COVID-19. Neutralization of cationic proteins (such as neutrophil extracellular trap–derived [NET-derived] histones) with polyanionic compounds...

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Detalles Bibliográficos
Autores principales:	Shi, Hui, Gandhi, Alex A., Smith, Stephanie A., Wang, Qiuyu, Chiang, Diane, Yalavarthi, Srilakshmi, Ali, Ramadan A., Liu, Chao, Sule, Gautam, Tsou, Pei-Suen, Zuo, Yu, Kanthi, Yogendra, Farkash, Evan A., Lin, Jiandie D., Morrissey, James H., Knight, Jason S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492316/ https://www.ncbi.nlm.nih.gov/pubmed/34264868 http://dx.doi.org/10.1172/jci.insight.149149

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