Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

Islet-enriched transcription factors (TFs) exert broad control over cellular processes in pancreatic α and β cells, and changes in their expression are associated with developmental state and diabetes. However, the implications of heterogeneity in TF expression across islet cell populations are not...

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Detalles Bibliográficos
Autores principales: Shrestha, Shristi, Saunders, Diane C., Walker, John T., Camunas-Soler, Joan, Dai, Xiao-Qing, Haliyur, Rachana, Aramandla, Radhika, Poffenberger, Greg, Prasad, Nripesh, Bottino, Rita, Stein, Roland, Cartailler, Jean-Philippe, Parker, Stephen C.J., MacDonald, Patrick E., Levy, Shawn E., Powers, Alvin C., Brissova, Marcela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Resource and Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492318/
https://www.ncbi.nlm.nih.gov/pubmed/34428183
http://dx.doi.org/10.1172/jci.insight.151621

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